Anti-Ox-LDL Antibodies and Anti-Ox-LDL-Β2GPI Antibodies in Patients with Systemic Lupus Erythematosus
Journal Title: Advances in Clinical and Experimental Medicine - Year 2012, Vol 21, Issue 3
Abstract
[b]Objectives[/b]. The aim of the study was to assess the concentration of anti-oxidized low-density lipoprotein (antioxLDL) antibodies and antibodies against oxLDL-β2GPI (oxLDL-beta 2 glycoprotein I) complexes in the serum of patients with systemic lupus erythematosus (SLE). Correlations between clinical and laboratory factors and the intima media thickness (IMT) were also investigated. [b]Material and Methods.[/b] The study included 16 patients (14 females, 2 males) with an established diagnosis of SLE. The mean disease duration was 6.3 years (range: 2–23 years). Thirteen age-matched healthy volunteers comprised the control group. IMT, the concentration of anti-oxLDL and anti-oxLDL-β2GPI antibodies and lipid profile were assesed. Data concerning other cardiovascular risk factors were also collected. [b]Results.[/b] In the SLE group the intima media was significantly thicker than in control group. In the SLE group a statistically significant positive correlation was noted between age and mean IMT. Immunological assays revealed elevated serum concentration of anti-oxLDL antibodies in the SLE group; serum concentration of IgG anti-oxLDL- β2GPI antibodies and IgM anti-oxLDL-β2GPI antibodies were also elevated in the SLE group compared to the controls. There was a statistically significant positive correlation between LDL concentration and anti-oxLDL antibody concentration in the SLE group. [b]Conclusions.[/b] The study findings support the thesis that cardiovasular risk is significantly higher in SLE patients. Elevated concentrations of anti-oxLDL antibodies, IgG anti-oxLDL-β2GPI antibodies and IgM anti-oxLDL-β2GPI antibodies were detected in the SLE group, which may contribute to the elevated cardiovascular risk in SLE patients
Authors and Affiliations
Beata Nowak, Magdalena Szmyrka-Kaczmarek, Anna Durazińska, Rafał Płaksej, Krzysztof Borysewicz, Lucyna Korman, Piotr Wiland
Keywords
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