Anti-oxidant and Anti-inflammatory Activities of Manilkara zapota (Sapodilla) In vitro and Efficiency in Healthy Elderly Persons
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 15, Issue 2
Abstract
Sapodilla is one of many fruits that has been consumed in all people in Thailand, especially in the elderly. The aim of this preliminary was to evaluate the antioxidant compounds, radical scavenging and anti-inflammatory activities of ripe sapodilla extracts, and the effects of their consumption on antioxidants, vitamins, lipid profiles, cytokines, and walking distance in healthy elderly volunteers. Vitamin A, E and C, total phenolics, the activity of scavenging Superoxide (O2o-), Hydroxyl (OHo), Hydrogen Peroxide (H2O2) and Nitric Oxide (NO), and inhibition of Tumor Necrosis Factor-Alpha (TNF-α) were identified in vitro. Whereas in elderly subjects, Total Antioxidant Capacity (TAC), Glutathione (GSH), Malondialdehyde (MDA), Protein Hydroperoxide (PrOOH), Nitric Oxide (NO), vitamins, lipid profiles (triglyceride, cholesterol, high-density lipoprotein-cholesterol; HDL-C, low-density lipoprotein; LDL), glucose, TNF-α, interleukin (IL-23 and IL-2), and 6- Minute Walking Distance (6MWD) were evaluated before and after 4-week consumption of 100 g of fresh sapodilla fruit twice daily. Results specific to in vitro data showed that sapodilla extract contained vitamin C and A, total phenolics, scavenged OHo, O2o-, NO, and H2O2, and inhibited TNF-α in a dose-dependent manner. The results in elderly individuals showed a significant increase of TAC, and vitamin C and A, while the NO level decreased. A significant decrease in cholesterol and increase in glucose with no significant change in all cytokines, were noted after consumption. Finally, the 6MWD improved significantly. This preliminary study demonstrates that ripe sapodilla fruit shows antioxidant and anti-inflammatory activities and benefits for health status among elderly persons.
Authors and Affiliations
Jirakrit Leelarungrayub, Thanyaluck Sriboonreung, Jynwara Kaju, Rungthip Puntumetakul
Keywords
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- EP ID EP591711
- DOI 10.26717/BJSTR.2019.15.002684
- Views 187
- Downloads 0
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