ANTI-OXIDANT AND ANTI-MICROBIAL ACTIVITIES OF SYNTHETIC 3-FORMYL, 7-FLAVONOL INTERMEDIATES OBTAINED BY MICROWAVE ASSISTED TECHNIQUE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 6
Abstract
Objective: The synthesized compounds of 3-formyl, 7-flavonols*, after characterization, aimed to be tested for their anti-oxidant and anti-microbial activities.Methods: i) anti-oxidant activities by hydrogen peroxide-nitric oxide-and by alkaline DMSO-methods and ii) anti-microbial activities against various gram-negative and gram-positive pathogens and against candida albicans by disc diffusion method.Results: Findings were found to be dose dependent and IC50 value was 30-60 µg/ml and the results revealed that the dinitro-, trinitro-and acetyl, dinitro derivatives showed better and/or equipotent activity to that of the standard, ascorbic acid. The synthesized compounds at a concentration of (1 μg/10 μl/disc) showed variable inhibitory activities against all bacteria with inhibition zone diameters ranging from 7-26 mm and a good antifungal activity against Candida albicans at the concentration of (1 μg/10 μl/disc) with inhibition of 10-24 mm. Klebsiella tribatta are more susceptible to the action of the formylated samples, giving high inhibition values comparing to the other organisms. Compounds Ie and Ih resulted to a higher activity index (AI>1); compounds Id, Ig and Ii showed an equal value (AI=1); whereas, Ia, Ib, Ic and If showed only a moderate activity (AI<1) compared to the standard, Amikacin.Conclusion: The findings confirmed that the synthetic compounds of 3-formyl, 7-flavonol derives have significant anti-oxidant and anti-microbial activities.*Synthesis and characterization work of 3-formyl, 7-flavonols has already been accepted for publication by the journal Elseveir, Procedio Chemistry and is in process.Â
Authors and Affiliations
Karpakavalli Meenakshi Sundaram, Usha Raja Nanthini, Sangilimuthu Alagar Yadav, Sivakumar Thangavel
Keywords
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