ANTI-PYRETIC ACTIVITY OF ETHANOLIC EXTRACT OF MERREMIA EMARGINATA (BURM. F) HALLIER F. IN RAT
Journal Title: International Journal of Pharmaceutical Applications - Year 2011, Vol 2, Issue 4
Abstract
Pyrexia is the increase of body temperature than the normal due to metabolic disturbances. Antipyretic drugs are widely used in the treatement of fever and pain. But the greatest disadvantage in presently available synthetic drugs is that they cause gastrointestinal irritation and reappearance of symptoms after discontinuation. Merremia emarginata (Burm. f) Hallier f. (Convolvulaceae) is a perennial, much branched herb. In the indigenous system of medicine, Merremia emarginata has been claimed to be useful for cough, headache, neuralgia, rheumatism, diuretic, treatment of inflammation, epilepsy, troubles of nose etc. The ethanolic extract of the plant was prepared and screened for antipyretic activity. The acute toxicity studies also carried out. pyrexia was induced using cow’s milk 2ml/kg i.p.. The test drug M.emarginata at a dose of 200mg/kg i.p. possessed significant antipyretic activity. The activity was very comparable to standard drug paracetamol 150 mg/kg i.p.
Authors and Affiliations
Rajalakshmi . R, , Indumathy. S, Gausunnisha. T, , Roselin . A, , Thamizharasy . P , Department of pharmacology, MTPG&RIHS, Puducherry. India
Keywords
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