Anti-repulsive Guidance Molecule C (RGMc) Antibodies Increases Serum Iron in Rats and Cynomolgus Monkeys by Hepcidin Downregulation

Journal Title: The AAPS Journal - Year 2015, Vol 17, Issue 4

Abstract

The online version of this article (doi:10.1208/s12248-015-9770-4) contains supplementary material, which is available to authorized users.

Authors and Affiliations

Preethne Böser, Dietmar Seemann, Michael J. Liguori, Leimin Fan, Lili Huang, Mathias Hafner, Andreas Popp, Bernhard K. Mueller

Keywords

Related Articles

Large Molecule Specific Assay Operation: Recommendation for Best Practices and Harmonization from the Global Bioanalysis Consortium Harmonization Team

The L2 Global Harmonization Team on large molecule specific assay operation for protein bioanalysis in support of pharmacokinetics focused on the following topics: setting up a balanced validation design, specificity tes...

Aqueous and cosolvent solubility data for drug-like organic compounds

Recently 2 QSPR-based in silico models were developed in our laboratories to predict the aqueous and non-aqueous solubility of drug-like organic compounds. For the intrinsic aqueous solubility model, a set of 321 structu...

Evaluation of Methods for Estimating Time to Steady State with Examples from Phase 1 Studies

An overview is provided of the methodologies used in determining the time to steady state for Phase 1 multiple dose studies. These methods include NOSTASOT (no-statistical-significance-of-trend), Helmert contrasts, splin...

Neuropeptide-processing enzymes: Applications for drug discovery

Neuropeptides serve many important roles in communication between cells and are an attractive target for drug discovery. Neuropeptides are produced from precursor proteins by selective cleavages at specific sites, and ar...

Key elements of bioanalytical method validation for small molecules

Method validation is a process that demonstrates that a method will successfully meet or exceed the minimum standards recommended in the Food and Drug Administration (FDA) guidance for accuracy, precision, selectivity, s...

Download PDF file
  • EP ID EP680976
  • DOI  10.1208/s12248-015-9770-4
  • Views 51
  • Downloads 0

How To Cite

Preethne Böser, Dietmar Seemann, Michael J. Liguori, Leimin Fan, Lili Huang, Mathias Hafner, Andreas Popp, Bernhard K. Mueller (2015). Anti-repulsive Guidance Molecule C (RGMc) Antibodies Increases Serum Iron in Rats and Cynomolgus Monkeys by Hepcidin Downregulation. The AAPS Journal, 17(4), -. https://europub.co.uk/articles/-A-680976