Anti-stress effect of Centella asiatica in rats
Journal Title: Scholars Academic Journal of Biosciences - Year 2015, Vol 3, Issue 8
Abstract
Abstract: Stress is considered to cause psychosomatic disorders. A group of plant based drugs, the adaptogens, increase the capacity of body to respond to stressful stimuli. Panax ginseng, a known adaptogen was taken as a standard drug. The present study evaluated adaptogenic/antistress potential of high altitude medicinal plant, Centella asiatica in a widely accepted immobilization stress model in rats. Male SD rats were exposed to immobilization once for 150 min only in acute stress and 7 consecutive days for chronic stress. This model has been shown to induce significant physiological, biochemical and neurochemical perturbations during acute and chronic stress exposure which could be attenuated by putative adaptogenic agents in rats. After stress, rats were sacrificed immediately, blood was collected and plasma separated for biochemical estimation. The biochemical estimation of plasma glucose, triglycerides, cholesterol, corticosterone and creatine kinase in stressed rats pretreated with Centella asiatica at different doses (100, 200 and 400 mg/kg, p.o) showed that it imparted adaptogenic/antistress activity. Keywords: antistress, C. asiatica.
Authors and Affiliations
Jeevan Chandra, Himanshu Joshi, Pankaj Bahuguna, Vivek Kumar Kedia, Rakesh Kumar
Keywords
Related Articles
- EP ID EP377974
- DOI -
- Views 60
- Downloads 0
Analysis about Seasonal Dissimilarity of Endophytic Bacteria Isolated from different Indigenous Plants
Abstract: Bacterial endophyte infect host plant without causing any detectable symptoms, these groups of bacteria are generally persistent. In all fifteen Indigenous plants were selected for isolation of endophytic bacte...
Effect of increasing load exhaustive exercise on oxidative stress of skeletal muscle in different parts of rat
Abstract: To explore oxidative stress condition of skeletal muscle in different parts of rat under the influence of the increasing load exhaustive exercise. Divide the 7-week-old SD male rats into two groups: quiet group...
Research Progress of Trehalose-6-phosphate synthase Gene (TPS) in Resurrection Plants
Abstract: Trehalose-6-phosphate synthase (TPS), as the key enzyme for the synthesis of plants trehalose, has effects of enhancing its anti-dehydration, as well as protecting biofilm, proteins, and others from harm. Addit...
Influence of Modified Cryopreservation Protocol on Sperm Retrieval Rate
Desire to leave genetic footprints has been a long cherished dream of mankind. The concept of sperm banking has fulfilled these desires by preserving gametes and genital tissues. Cryo banking of spermatozoa is an essenti...
Statistical Relationship between Liver Weight and Length of Intestine of Carcharhinuslimbatus(J. P. Muller &Henle, 1839) From Sassoon Docks
The present research was carried out to establish relationship between Liver Weight and Length of intestine of Carcharhinuslimbatusfrom Sassoon docks. The mean value of Liver Weight is 3.66 ± 0.49, while that of Length o...