Anti-ulcerogenic activity of stem extract and fractions of Homalium letestui
Journal Title: Journal of Herbal Drugs - Year 2015, Vol 6, Issue 1
Abstract
Background & Aim: Homalium letestui Pellegr (Flacourtiaceae) used traditionally by the Ibibios of Southern Nigeria to treat stomach ulcer, malaria and other inflammatory diseases was evaluated for antiulcer properties. Experimental: The effects of ethanol stem extract of H. letestui (200 – 600 mg/kg) and fractions (Aqueous and Dichloromethane, 400 mg/kg) on experimentally induced ulcer were studied in rats using ethanol, indomethacin, reserpine and histamine –induced ulcer models. Results & Discussion: The extract (200 – 600 mg/kg) inhibited ethanol, indomethacin, reserpine and histamine –induced ulcer models in a dose dependent fashion. The various degrees of inhibitions were statistically significant (p<0.05, 0.01, 0.001). The effects of the extract/fraction were comparable to that of the standard drugs used in indomethacin and ethanol-induced ulcer models with the dichloromethane fraction having the highest activity. Industrial and practical recommendations: The present study demonstrates that stem extract of Homalium letestui might to be useful for the treatment of ulcer.
Authors and Affiliations
Louis U. Amazu; Jude E. Okokon; Lucky L. Nwidu
Keywords
Related Articles
- EP ID EP23474
- DOI -
- Views 302
- Downloads 21
Effects of aluminosilicate zeolite application on morphological traits and chemical compositions of Aloe (Aloe vera L.) under drought stress
Background & Aim: Aloe vera is used in the food and pharmaceutical as an aid to effective treatment. The purpose of this study is to improve growth, increase production of valuable metabolites and increase the sugars in...
Effect of methanol and ethanol application on yield of Echinacea purpurea L. in Karaj region
Background & Aim: This experiment investigated the effect of foliar application of methanol and ethanol on the biomass yield of medicinal plant Echinacea purpurea. Purple coneflower is an herbaceous perennial in the Aste...
The examination of intellectual right of medicinal plants and the issue of bio-theft due to agreement of TRIPS
Over the past two decades, the role of intellectual property rights in all areas of science and technology has exploded globally– primarily due to the rules prescribed by the World Trade Organization’s TRIPS and by bilat...
Using elicitors for enhanced production of secondary metabolites in plant cell and organ suspension cultures
In biotechnology has been concentrated to review alternative routes for the production of natural compounds. Plant cell culture systems are viable alternatives for the production of secondary metabolites that are of comm...
The study of burn healing of Onosma stenosiphon on type II burn of back and testis areas in rats
Background & Aim: Onosma stenosiphon has been used as herbal medicine for healing skin cuts and rashes. However, burn healing effect of this herb has not been yet reported in pharmaceutical texts. The aim of this study w...