ANTIATHEROSCLEROTIC AND ANTIOXIDANT POTENTIAL OF PETROLEUM ETHER EXTRACT OF PROSOPIS CINERARIA POD IN HYPERCHOLESTEROLEMIC RABBITS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 6
Abstract
Objective: The present study is done to investigate the anti-atherosclerotic efficacy of petroleum ether extract of Prosopis cineraria pod in hypercholesterolemic diet-induced atherosclerosis in rabbits. Methods: Atherosclerosis was induced in rabbits by feeding normal diet supplemented with oral administration of cholesterol (500 mg/kg body weight/day) which was mixed in coconut oil for 15 days. Rabbits were then administered with petroleum ether extract of P. cineraria pod for 45 days (Group III), and another set of the group was treated with standard drug Atorvastatin for 45 days. After the completion of the experimental period, the serum biochemistry and histological analysis of thoracic aorta was done. Along with it lipid peroxidation(LPO) and antioxidant parameters such as catalase (CAT), superoxide dismutase (SOD), and ferric reducing ability of plasma (FRAP) were estimated. Results: There was a significant increase (p≤0.001) in serum total cholesterol (TC), low density lipoprtein (LDL) and triglycerides after cholesterol feeding when compared with the control group (Group I). Antioxidant parameters were altered too with an increased serum LPO while the reduction in CAT, SOD, and FRAP was observed. After the administration of the petroleum ether extract, significant reduction in TC, LDL-C, very low-density lipoprotein -C, and triglyceride was observed as compared to high-fat diet control rabbits. Slightly significant reduction in (p≤0.05) atherosclerotic plaque in the aorta was observed while cardiac LPO was lowered alternatively CAT, SOD, and FRAP levels increased in petroleum ether extract administered rabbits. Conclusion: The outcomes from this study recommend that P. cineraria pod extract has hypocholesterolemic effect thereby controlling atherosclerosis and has potent antioxidant activity which may be responsible for improving the lipid profile.
Authors and Affiliations
NOOPUR JAIPAL , HEERA RAM
Keywords
Related Articles
- EP ID EP608973
- DOI -
- Views 113
- Downloads 0
COMPARATIVE ASSESSMENT OF THERAPEUTIC POTENTIAL OF VACHADI AND HINGWADI GHTRITA IN PATIENTS OF DEPRESSION
 Objective: Present exploratory clinical study dealt with comparative assessment of therapeutic effect of medicated ghee formulations i.e. Vachadi [VG] and Hingwadi Ghrita [HG] in patients of mild to moderate depression...
ANTI-INFLAMMATORY EFFECT OF LIPID EXTRACT OF SEA PEN (VIRGULARIA GUSTAVIANA) IN MICE
 Objective: Sea pens are a highly specialized group of anthozoa coelenterates. Sea pens were collected by wading at low tide in intertidal zone fromBandar Abbas Costal.Method: Sea pens were identified by classification...
DESIGN AND STATISTICAL OPTIMIZATION OF MOUTH DISSOLVING SUBLINGUAL FILM OF FIXED DOSE COMBINATION OF DOXYLAMINE SUCCINATE AND PYRIDOXINE HYDROCHLORIDE USING DESIGN OF EXPERIMENT IN THE TREATMENT OF NAUSEA AND VOMITING IN PREGNANCY
Objective: The present research aims at formulating a mouth dissolving sublingual film of fixed dose combination of doxylamine succinate (DS) and pyridoxine hydrochloride (PH) that would provide faster onset of action an...
METHOD DEVELOPMENT AND VALIDATION OF UV-VISIBLE SPECTROSCOPIC METHOD FOR THE ESTIMATION OF ASSAY OF SUGAMMADEX SODIUM, APREMILAST, RIOCIGUAT AND VORAPAXAR SULFATE DRUGS IN API FORM.
Objective: The objective of the present work is to develop a simple, efficient and reproducible spectrophotometric method for the quantitative estimation of Sugammadex Sodium, Apremilast, Riociguat and Vorapaxar sulfate...
EFFECT OF STREBLUS ASPER LEAVES ON LOCOMOTION, ANXIETY AND COGNITION IN RATS
Objective: The current study deals with the evaluation of neuropharmacological activities of hydroalcoholic extract of the plant Streblus asper. Methods: Hydroalcoholic extract of S. asper leaves was administered to an...