ANTIBACTERIAL ACTIVITY OF DIFFERENT EXTRACTS OF STEM BARK OF HOLOPTELEA INTEGRIFOLIA ROXB (PLANCH)
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 1
Abstract
The petroleum ether, benzene, chloroform, methanol and aqueous extracts of the stem bark of Holoptelea integrifolia were evaluated for the antibacterial activity against various microorganisms viz Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa. Disc diffusion method was adapted for the assessment of in vitro antibacterial activity. The antibacterial activity of different extracts of Holoptelea integrifolia at various concentrations were evaluated where zone of inhibition was compared with the standard drug i.e. ampicillin. Chloroform extract was found to be very effective against all the test microorganisms used; petroleum ether extract was only effective against P. aeruginosa; benzene extract was effective against E.coli and B.subtilis; methanol extract was effective against E.coli and aqueous extract was effective against S.aureus and E.coli, respectively when compared to standard drug ampicillin. The minimum inhibitory concentration for chloroform extract was found to be 50,300,25 and 100 μg/ml against S.aureus, B. subtilis, E. coli and P. aeruginosa; for petroleum ether extract was 100 μg/ml (P. aeruginosa); for benzene extract was 100 μg/ml (E.coli) and 25 μg/ml (B. subtilis); for methanol extract was 100 μg/ml (E.coli) and for aqueous extract was 50 μg/ml (S. aureus) and 25 μg/ml (E. coli) respectively suggesting the antibacterial activity of Holopteleaintegrifolia.
Authors and Affiliations
Durga Nadella , Padmaa M Paarakh
Keywords
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