ANTIBACTERIAL ACTIVITY OF IMIDAZO [1,2-α] PYRIDINYLCHALCONES DERIVATIVES AGAINST ENTEROCOCCUS FAECALIS

Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 11

Abstract

The emergence of nosocomial strains of Enterococcus faecalis and drug resistance that antibiotics faces in the treatment of enterococcal infections, prompted us searching for new more efficient bioactive molecules For this purpose, 10 chalcones based imidazo[1,2-a]pyridine (5a-5d) were synthesized and assessed for their antibacterial activity against susceptible and resistant strains of Enterococcus faecalis. The screening was fulfilled using the agar diffusion method to select best molecule, then by the method of dilution in liquid medium compared to Amoxicillin and Gentamicin. The compounds 5h and 5d, with respective MIC 44.6 μM and 9.9 μM, exhibited the best antibacterial profiles. It appears from the structure activity relationship studies that the presence of fluorine on the benzene homocycle or replacement of this homocycle by a furan ring lead to significant antibacterial activities. Paradoxically, all activities were more effective against resistant strains than on sensitive ones. Compounds 5h and 5d may constitute seeds of a new class of antibacterial effective against resistant Enterococcus faecalis.

Authors and Affiliations

Mahama Ouattara

Keywords

Related Articles

A STUDY OF WOUND INFECTIONS AND MICROBIAL WOUND ISOLATES AT PRINCE SAUD BIN JALAWI HOSPITAL, SAUDI ARABIA

Introduction: The wound is a breach in the integrity of skin that leads to subcutaneous tissue exposure. Wound infection is one of the principal cause of patient morbidity and mortality. They are also considered one of t...

ISOLATION AND BIOACTIVITY OF ESSENTIAL OIL OF ELETTARIA SP AGAINST SOME PATHOGENIC BACTERIA

The current study included volatile oil extraction from Elettaria sp plant and diagnosis composite Using some chemical spectral techniques such as Infra-Red spectrum (IR and Gas Chromatography Mass (GC\Mass) 34 compound...

QUALITY ANALYSIS OF DIFFERENT MARKETED BRANDS OF ATENOLOL (50 MG) TABLETS AVAILABLE IN SYRIA AND COMPARING WITH THE REFERENCE DRUG

There are numerous generics of atenolol tablets available in Syria. The purpose of current study is to assess the physicochemical characters of four brands(A, B, C, D) of atenolol(50mg) tablets advertised in Syria and co...

CAN GARCINIA COCHINCHINENSIS CHOISY AFFECT FOOD INTAKE AND BEHAVIOR IN EXPERIMENTAL MODELS?

Studies have demonstrated an intrinsic relationship between obesity and anxiety, highlighting anxiety as both a frequent symptom among the obese and its strong relationship with an increase in food consumption. The objec...

THE PREVALENCE OF RISK FACTORS OF DIABETES MELLITUS AMONG NORMAL POPULATION IN AL MADINAH AL MONAWARRAH

Background: There is a spread in the number of prevalence of DM in Saudi Arabia. This was the main motivation to start working on a method to identify individuals who had high score in the risk factor assessment. Objecti...

Download PDF file
  • EP ID EP627571
  • DOI -
  • Views 139
  • Downloads 0

How To Cite

Mahama Ouattara (2018). ANTIBACTERIAL ACTIVITY OF IMIDAZO [1,2-α] PYRIDINYLCHALCONES DERIVATIVES AGAINST ENTEROCOCCUS FAECALIS. World Journal of Pharmaceutical Research, 7(11), 21-33. https://europub.co.uk/articles/-A-627571