ANTIBACTERIAL AND ANTIOXIDANT ACTIVITIES OF METHANOLIC EXTRACT OF BAUHINIA RACEMOSA
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 2
Abstract
Objective: To evaluate antimicrobial and in vitro [s1] antioxidant activities of methanolic extract of Bauhinia racemosa leaf.Methods: The antimicrobial activity was determined by the agar-well diffusion method. The antioxidant potential was evaluated by using various in vitro [s2] methods such as 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2, 2-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid) (ABTS), phospho molybdenum reduction assay and ferric (Fe 3+) reducing power assays.Results: The maximum inhibition zone (26 mm) was found against Proteus mirabilis while lowest inhibition zone (20 mm) was observed against Acinetobacter baumannii.The DPPH and ABTS were significantly inhibited by methanolic extract of Bauhinia racemosa leaf with IC50 of 9 μg/ml and 550μg/ml respectively, whereas methanolic extract of leaves showed good antioxidant potential using ferric reducing power assay (1.896[s3] and phosphomolybdate assay (108.12 mg AAE/g) methods.Conclusion: The results of present study showed that Bauhinia racemosa leaf possesses high potential antimicrobial and antioxidant activity and could be a potential source of natural antioxidant that could have great importance as therapeutic agents in preventing oxidative stress-related degenerative diseases.Keywords: Bauhinia racemosa, Antimicrobial, In vitro [s4] antioxidant, DPPH, ABTS, FRPA. [s1]italic [s2]italic [s3]IC50 or what? [s4]italic
Authors and Affiliations
Pritipadma Panda, Abhisek Pal, Laxmidhar Maharana, Goutam Ghosh
Keywords
Related Articles
- EP ID EP577885
- DOI -
- Views 49
- Downloads 0
ETHNOMEDICINAL, PHYTOCHEMICAL AND PHARMACOLOGICAL ASPECTS OF FLACOURTIA JANGOMAS: A REVIEW
Flacourtia jangomas (Lour.) Raeusch., a small tree of Willow family distributed throughout tropical regions of East Africa and Asia is well-known for its culinary and medicinal uses. The plant has received increasing int...
TOXICITY AND MOLECULAR DOCKING STUDIES OF TETRAHYDROQUINOLINES AGAINST MICROBIAL, CANCER, RETINOIC ACID RECEPTOR, INFLAMMATORY, CHOLESTEROL ESTER TRANSFERASES AND PARASITIC PROTEIN RECEPTORSTOXICITY AND MOLECULAR DOCKING STUDIES OF TETRAHYDROQUINOLINES AG
Objective: Synthesis of 2-methoxy-4-(3-methyl-2-phenyl-1,2,3,4-tetrahydroquinolin-4-yl)phenol derivatives (4a-i) and to study their inhibitory effects towards inflammatory, cancer, retinoic acid, cholesterol esterase, pa...
IN SILICO ANALYSIS OF INTERACTIONS IN HEME BINDING PROTEINS
Objective: Heme cofactors are essential molecule found in almost all forms of life. Biological systems depend on heme-protein interactions to carry out basic functions required for their survival. The objective of the pr...
SIMULTANEOUS ESTIMATION OF LOPERAMIDE HYDROCHLORIDE AND TINIDAZOLE IN BULK AND FORMULATIONS BY REVERSE PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
Objective: A new, rapid, selective, precise, accurate and economical, isocratic, reverse phase high-performance liquid chromatography method has been developed for simultaneous estimation of loperamide hydrochloride and...
COMPARISON STUDY OF THERAPEUTIC PROPERTIES OF PROTEINS AND SECONDARY METABOLITES FROM CARICA PAPAYA
Objective: The current study aims to compare the therapeutic potential of protein extracts and secondary metabolites extracts using methanol, ethyl acetate and hexane from both the fruits and seeds of Carica papaya.Metho...