ANTIBACTERIAL COATINGS OF KNITTED BIO MATERIALS AGAINST BACTERIAL PATHOGENS USING SYNERGISTIC DRUGS
Journal Title: Journal of Pharmaceutical and Scientific Innovation - Year 2018, Vol 7, Issue 4
Abstract
The primary goal of the treatment of wound israpid closure and a functional and aestheticallysatisfactory scar. Wound healing is a dynamic, interactive processinvolving soluble mediators, blood cells, extracellularmatrix, and parenchymal cells. An improvement in the properties of wound healing textile was achieved through impregnating with antibacterial agents. In the present study, one such method was aimed to reduce the complications of wounds by coating wound healing knitted fabric with two different groups of synergistic drugssuch as(piperacillin and tazobactam), and a carrier beta cyclodextrin. The drug coated (piperacillin-tazobactam) and drug-carrier coated(piperacillin-tazobactam+ beta cyclodextrin)knitted fabrics were subjected to antibacterial activity against the wound pathogens. Among the four different concentration of synergistic drugs (piperacillin-tazobactam), 4X strength exhibited maximum inhibitory zones against all the test organisms. Maximum inhibitory zones of 21mm were observed against Escherichia coli and 19mm against Staphylococcus aureus. Antibacterial activity of drug-carrier coated (piperacillin-tazobactam+ beta cyclodextrin) knitted fabric showed maximum inhibitory zone of 31mm against Escherichia coli and Staphylococcus aureus respectively. When compared to drug coated knitted fabrics, drug-carrier coated knitted fabrics showed more antibacterial activity. This was mainly due to the inhibitory actions of the carrier;beta cyclodextrin.Thus the proposed research illustrated the significance of synergistic drug and carrier coatings on wound healing knitted fabrics. The developed product was thus aimed to prevent from complications like amputation in wound closure and a functional and aesthetically satisfactory scar.
Authors and Affiliations
Arice Mary M, Karpagam Chinnammal S
Keywords
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- EP ID EP631494
- DOI 10.7897/2277-4572.074100
- Views 43
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