ANTIBIOGRAM OF PREVALENT MICROORGANISMS IN WOUND INFECTIONS- A COMPARATIVE STUDY BETWEEN DIABETIC AND NON-DIABETIC PATIENTS ATTENDING A TERTIARY CARE HOSPITAL
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 85
Abstract
BACKGROUND Management of wound infections is a challenge even today due to inadequate understanding of microbial pattern and therapeutic approaches. This study was thus designed to identify the isolates to study the antibiograms of these isolates infecting the wounds of diabetic and non-diabetic patients in various departments of a tertiary care unit. MATERIALS AND METHODS 280 patients (diabetic and non-diabetic) with infected wounds were included in this study. Wound swabs (from HiMedia) were inoculated on Nutrient Agar, Blood Agar and MacConkey Agar media and incubated. Smears were prepared from the colonies thus obtained, Gram-stained followed by identification and confirmation of isolates as per standard microbiological guidelines. Their antibiotic sensitivity pattern was detected using Kirby-Bauer Disc Diffusion method on Mueller-Hinton Agar Medium as per CLSI guidelines. RESULTS In this study, it was found that gram negative bacterium Escherichia coli was most prevalent pathogenic organism both in diabetic and non-diabetic cases of wound infection. Staphylococcal isolates from non-diabetic patients showed maximum sensitivity towards Cefoperazone, among the Cephalosporins tested. Gram-negative bacteria showed greater sensitivity to Amikacin in nondiabetic and to Imipenem in diabetic patients. CONCLUSION Rate of wound infection was found to be more in diabetic patients when compared to non-diabetic patients. The prevalence of polymicrobial isolates was more in diabetic patients, which could be due to reduced host immune responses in them.
Authors and Affiliations
Yusra Fatima, Maimoona Mustafa
Keywords
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- EP ID EP277608
- DOI 10.14260/jemds/2017/1288
- Views 79
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