Antibiotic Sensitivity Pattern of Salmonella Typhi in a Stand Alone Lab in Central Madhya Pradesh
Journal Title: Indian Journal of Microbiology Research - Year 2016, Vol 3, Issue 1
Abstract
Introduction: Typhoid fever or enteric fever, is an endemic disease in many developing countries specially India and the Indian Subcontinent. In the past decade, resistance of Salmonella to multiple drugs is on the rise specially resistant to ampicillin, chloramphenicol and cotrimoxazole. This resistant pattern has resulted in use of Fluoroquinolones and third generation Cephalosporins as first line drugs.)The present study was under taken to study the antibiotic susceptibility pattern of S.typhi isolated from blood cultures in our microbiology laboratory. Materials and Methods: 766 patients suspected of having typhoid fever of different age groups and sex visiting our Microbiology department for blood culture were included in the study from January 2015 to December 2015. Gram negative non lactose fermenting colonies were subjected to identification and antibiotic susceptibility testing in Vitek II (Biomerieux) according to CLSI guidelines. Results: Out of 766 blood cultures, 32 cases of S.typhi were isolated. 561 cultures were sterile and 73 showed growth of other bacteria. Colistin, Cefuroxime, Imipenem, Meropenem showed 100% sensitivity. Piperacillin/Tazobactam, Tigecyline. Cefoperazone/Sulbactam were sensitive in 93.75% isolates. Amoxicillin/Clavulanic Acid (90.62%), Ceftazidime(87.5%), Trimethoprim/Sulfamethoxazole (87.5%), Ticarcillin(84.37%), Ampicillin (81.25%),Cefepime(78.12%), Cefalotin(75%), Amoxycillin(65.62%), Cefixime(59.37%). Cefoxitin(43.75%), Amikacin(31.25%), Gentamicin(6.75%), Ciprofloxacin was found to be resistant in all 32 cases(100%). Conclusion: There has been a reemergence in the sensitivity of Salmonella Typhi to Ampicillin, Ceftazidime, Cefuroxime Ceftriaxone, Cefoperazone/Sulbactum Cefipime and Amoxyclav and 100% resistance to Ciprofloxaxin and to Amikacin & Gentamycin. Cefuroxime, Ceftriaxone, Cefoperazone/Sulbactum seem to be good therapeutic options is our setting atpresent.
Authors and Affiliations
Ranjana Hawaldar, Sadhna Sodani, Hemlata Bhilware
Keywords
Related Articles
- EP ID EP240865
- DOI -
- Views 145
- Downloads 0
Bacteriological profile of diabetic foot infection with special reference to ESBL and MRSA in a coastal tertiary care teaching hospital
Introduction: One of the most important complications of diabetes mellitus is foot infection. Bacterial spectrum of diabetic foot infections vary greatly. The increasing association of multi-drug resistant (MDR) bacteria...
Detection of oxacillanase and metallobetalactamase in carbapenem resistant isolates of Acinetobacter spp., from various clinical samples by phenotypic and genotypic methods in a tertiary care hospital
Background: Non fermenting Gram Negative Bacilli (NFGNB) once considered as contaminants, now emerged as a major cause of life threatening nosocomial infections and as multidrug resistant pathogens. Acinetobacter species...
Prevalence of Hepatitis B Surface Antigen among Patients Attending a Rural Teaching Hospital at Puducherry
Background: HBV infection in humans is a global health problem which accounts for morbidity and mortality rates associated with its serious complications like cirrhosis of liver and carcinoma of liver. The incidence of H...
A study on bacterial infections and their antibiotic susceptibility pattern in decompensated liver disease patients in a tertiary care Hospital
Background & Objectives: Decompensated liver disease (DCLD) is defined as irreversible chronic injury of the hepatic parenchyma. Bacterial infections are more common in decompensated liver disease and causes 30%-50% of d...
Seroprevalence of transfusion transmissible infections among blood donors at tertiary care hospital in southern Telangana- A 3 year cross sectional study
Introduction: Transfusion of blood and blood products is lifesaving in clinical situations but sometimes it is also a potential source of infection to patients who receive it. Screening for TTIs (Transfusion Transmissibl...