Antibiotic susceptibility pattern in Proteeae with special pattern of Amp-C β- lactamase
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2016, Vol 2, Issue 1
Abstract
Amp C β -lactamases are reported from Enterobacteriaceae with increasing frequency. However, unlike Extended- spectrum β-lactamases (ESBLs), no screening and confirmatory tests have been uniformly established for strains that produce Amp C β -lactamases. They may not necessarily confer resistance to broad-spectrum cephalosporins when conventional CLSI breakpoints are used, although they may meet screening criteria for ESBLs. They typically have a negative confirmatory test for ESBLs and therefore laboratories may report Amp C producers as susceptible to broad- spectrum cephalosporins. This may have disastrous consequences if physicians erroneously use broad-spectrum cephalosporins to treat serious infections. Fortunately, several simple detection methods of class C β -lactamases have been reported recently. When ESBL production is suspected but the confirmatory tests are negative, the strains should be screened for the presence of class C β –lactamase. Reduced susceptibility to cefoxitin is a sensitive but not specific indicator of class C β -lactamase production. The ‘AmpC disk test’ may be incorporated into ESBL detection algorithms. The AmpC disk test was an easier, reliable and rapid method of detection of isolates that harbour AmpC β -lactamases. This suggests that AmpC disk test can be used for routine screening of the Amp C enzyme in the clinical laboratory.
Authors and Affiliations
A. Balasubramanian* J. Vinoth
Keywords
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