Antibiotic Therapy in Neonatal Sepsis
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 10
Abstract
A lot of bias exists in the management of suspected sepsis owing to the non-specific manifestations of sepsis in neonates resulting in injudicious use of antibiotics thereby increasing the risk of emergence of antibiotic resistance. Sepsis markers can help in detecting and managing sepsis more accurately. This study was conducted from June 2016 to June 2017 in the department of paediatrics in Gandhi Hospital, to determine whether normalization of CRP correlates with recovery from sepsis aiding the decision about the duration of antibiotic therapy .110 neonates with sepsis were studied prospectively. .A value of > 6 mg/L of CRP was taken as indicative of sepsis. If it was < 6mg/L antibiotics were stopped and patients were assigned to group 1.Neonates with CRP > 6mg/L were assigned to group 2 and are randomized into group 2A in which antibiotics were discontinued after 7 days if the CRP was negative and 2 B in which antibiotics were stopped as soon as CRP turned negative. All the babies were followed up for relapse for four weeks. CRP was negative on first estimation in 26 cases (23.6%) and antibiotics were stopped (Group 1). No relapse was observed. In the remaining 84(76.4%) cases, Group2, all the cases with positive blood culture were given standard therapy and were not followed up with serial CRP measurements. Fifteen babies from group 2 received antibiotics for seven days and antibiotics were stopped when CRP was found to be negative on 7th day (2A).Therapy was stopped based on negative CRP value on or before 7 days in 18 cases in group 2B. In group 2B, mean duration of treatment was 5.3 ± 1.1 days when compared to group 2A where it was 7 ± 1 days. No relapses were noted in both the groups. There is 100% negative predictive value of serial CRP measurement. This has implication in reducing the cost of therapy, duration of hospitalization and reducing the emergence of antimicrobial resistance.
Authors and Affiliations
A. Soumya, N. Srinivasa Suresh
Keywords
Related Articles
- EP ID EP478428
- DOI -
- Views 79
- Downloads 0
Prevalence of Anxiety and Depression with Psoriasis at a Tertiary Care Centre
Psoriasis is a chronic skin disorder with multisystem involvement. Musculoskeletal, cardiovascular, psychological, etc. A cross sectional study is done to know the prevalence of mood disorders in psoriatic patients. Ma...
A Study of Clinical Profile of Benign Breast Diseases Presenting at a Tertiary Care Centre in Central India
The objective of the work was to study the clinical profile of Benign Breast Diseases (BBD) and their correlation with ultrasonographic and histopathological findings at a tertiary care centre in Central India. The prese...
Prevention of Penile Gangrene Development after Strngulation of Penis with Metallic Nut by Degloving Method: A Case Report
Penile strangulation is one of severe damaging injury which may cause organ loss. It requires early intervention to avoid its disastrous sequelae. Removal of constricting objects is one of the challenging task in dealing...
Psychophysical effects of Music in Exercise
Abstract: For years researchers have investigated the effects of music on exercise performance. Humans respond to rhythmical qualities of music by synchronizing movement pattern to tempo. Synchronous music has shown to p...
Seroprevalence of Hepatitis B and C among blood donors attending a State of the Art Model Blood Bank of North East India
Abstract:Hepatitis B and C viruses though distinct share a common mode of transmission, primarily through unscreened and contaminated blood and blood products due to contact or through transfusion. This study was underta...