ANTICALCIC EFFECT OF AN AQUEOUS TRUNK BARK EXTRACT OF PARKIA BIGLOBOSA (JACQ. BENTH (MIMOSACEAE) ON THE SPONTANEOUS CONTRACTILE ACTIVITY OF THE ISOLATED HEART OF RAT
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2018, Vol 5, Issue 11
Abstract
Objective: Parkia biglobosa (Mimosaceae) is a plant used in African traditional medicine to treat hypertension and heart disorders. Cardiac activity is underlain by particularly calcium ionic flow through the myocardial membrane. We undertook this study of the effects of an aqueous trunk bark extract of Parkia biglobosa (EAPB) on the isolated heart of rat in modified physiological solutions in order to investigate its influence on the transmembrane transport of the calcium ion which is the main activator of the heart muscle or muscle contraction. Methods: The spontaneous contractile activity of the isolated rat heart is recorded in normal physiological solution and modified physiological solutions with a Langendorff- type device. Results: An aqueous extract of Parkia biglobosa (EAPB), at concentrations between 10-14 and 10-4 mg / ml induces cardiodepressant effects (negative inotropic and chronotropic effects) dose dependent. EAPB inhibits the positive inotropic effect induced by hypercalcic, hyposodic or hypopotassic physiological media that raises the calcium level; which allows to affirm that this substance is a calcium influx inhibitor or a slow calcium channel or voltage-dependent blocker (L-type channels). This characteristic is confirmed by the accentuation of the inhibitory action of EAPB in hypocalcic physiological medium, which reduces the calcium influx, and consequently the concentration of cytosolic calcium. Conclusion: This study shows that EAPB exerts on the isolated heart an anti-calcic effect responsible for its cardiodepressor effects.
Authors and Affiliations
Semi Anthelme Nene Bi
Keywords
Related Articles
- EP ID EP639675
- DOI -
- Views 120
- Downloads 0
CORRELATION OF SERUM CHOLESTEROL, ELECTROLYTES, AND BODY MASS INDEX WITH CARDIOVASCULAR STATUS OF SELECTED ADULTS IN BAYELSA STATE NIGERIA.
This study investigated the correlation of serum cholesterol, electrolytes, age and body mass index, with cardiovascular status of selected adults in Bayelsa State. The study subjects comprises, 94 males and 86 females b...
GREEN CHEMISTRY IN DRUG DESIGN- A REVIEW
Green chemistry or environmentally benign chemistry is the design of chemical products and processes that reduce or eliminate the use and generation of hazardous substances. Green chemistry emerged from a variety of exis...
“BIOENERGY-CHALLENGES AND OPPORTUNITIES IN PAKISTAN”
Energy being significant environmental issue globally plays a key role in modern society and can serve as an important component in socio-economic development of a country. For the establishment and development of bio- e...
ISOLATION AND CHARACTERIZATION OF SOIL-BORNE UREASE PRODUCING BACTERIA
Urease producing bacteria are significant for their increasing roles in human pathogenicity, biocementation and as soil fertilizer. This study was therefore aimed at isolation of such urease producers from urea-rich soil...
COMPARATIVE STUDY OF CERTAIN COMMERCIALLY AVAILABLE BRANDS OF PARACETAMOL TABLETS IN SANA'A CITY, YEMEN
Evaluation of the physiochemical properties of the pharmaceutical products can ensure their quality as well as bioavailability and impart optimum therapeutic activity. In general, drugs must be marketed as safe and thera...