Anticancer activity of Eugenia jambolana seeds against Hep2 cell lines
Journal Title: The Journal of Phytopharmacology - Year 2015, Vol 4, Issue 6
Abstract
Cancer is a life-threatening disease and leads to high rates of mortality worldwide, after cardiovascular disease, is the second leading cause of death. Investigations for finding new plant based anticancer compounds are imperative and interesting. There are many studies on anticancer herb/plant extracts in cell line models. Eugenia jambolana has been reported to contain phytochemicals like coumarin, flavanoids, glycosides, phenols, tannins and steroids. The various part of Eugenia jambolana have therapeutic applications. Plant active components were extracted using the decoction extraction method and the filtrate was obtained by means of filtering through a Whattman no.1 filter paper. The filtrate was evaporated in a weighed flask in a hot air oven set at 50°C. Extracts were reconstituted by re-dissolving in respective solvents. Different concentration i.e. 8, 15.6, 31.25, 62.5, 125, 250, 500 and 1000 µg. of the plant extracts were tested for the anticancer activity. The anticancer assay was performed on Human laryngeal epithiloma cells (Hep 2) obtained from King Institute of Preventive Medicine, Chennai, India. The cell viability was measured using MTT assay. Controls were maintained throughout the experiment (Untreated wells as cell control and diluent treated wells as diluent control). The assay was performed in triplicates for each of the extracts.
Authors and Affiliations
Denis Mabeya Ogato Eliakim Mbaka Mauti, Godfrey Omare Mauti, Barasa Ambrose, David Keno Kowanga
Keywords
Related Articles
- EP ID EP49657
- DOI -
- Views 168
- Downloads 0
Anticonvulsant actions of ethanol stem bark extract of Trichilia roka (Meliaceae) in mice and chicks
The current antiseizure drugs present with side effects, some of which can lead to discontinuation of epilepsy pharmacotherapy, and a sizeable number of other drugs being less efficacious. Medicinal plants are used for...
Resistance modulation studies of vernolide from Vernonia colorata (Drake) on ciprofloxacin, amoxicillin, tetracycline and erythromycin
Resistance modulatory activities of natural products on traditional antibiotics have gained scientific interest in recent years. This is aimed at maximizing antimicrobial potency with major strides in curbing microbial...
Evaluation of lipogenic property of Phragmanthera capitata in diabetic rats
Objective: Phragmanthera capitata is a parasitic plant employed in the treatment of wide range of disorders in Cameroon folkloric medicine. The present study was carried out to evaluate lipogenic property of aqueous ex...
A prospective study of prathisaraneeya apamarga kshara in comparison with prathisaraneeya palasha kshara in patients with charmakeela (warts) and kadara (corns)
Background: Charmakeela and Kadara are the diseases which have signs and symptoms similar to Warts and Corns respectively. Objectives: Kshara karma is mentioned under kshudra roga adhikaras by Acharya Sushruta under th...
A review on Ficus palmata (Wild Himalayan Fig)
Traditionally, various plants are used for treatment of many diseases. Ficus palmata is a herbaceous perennial plant belonging to the family Moraceae. It contains a very juicy fruit and is used for making various produ...