ANTICANCER POTENTIAL OF α-MANGOSTIN
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2017, Vol 10, Issue 12
Abstract
Objective: Mangosteen (Garcinia mangostana Linn.) is a tropical fruit originated from South East region. Mangosteen exhibiting a variety of pharmacological activities and is often used for traditional medicine. There are numerous chemical compounds contained in the pericarp of the mangosteen fruit. One of them is xanthone derivative which in some studies shows antioxidant and anticancer activity by preventing free radical and damaging cells. One of the xanthone derivatives that have the strongest anticancer properties is α-mangostin.Methods: Anticancer potential of α-mangostin was reviewed from available literature.Results: The α-mangostin shows anti-proliferative and apoptotic activity by suppressing the formation of carcinogenic compounds in various cancer cells. This review will summarize the anticancer properties of α-mangostin that may be exploited for effective cancer prevention.Conclusion: Development of α-mangostin as a chemopreventive compound can provide new opportunities for effective cancer drug discovery. α-mangostin is useful as a complementary or alternative medicine and a chemopreventive tool against cancer.
Authors and Affiliations
Muchtaridi Muchtaridi, Cindy Aprillianie Wijaya
Keywords
Related Articles
- EP ID EP605587
- DOI 10.22159/ajpcr.2017.v10i12.20812
- Views 91
- Downloads 0
EFFECT OF FACETAL JOINT MOBILIZATION IN LUMBAR SPONDYLOSIS.
 Objectives: Lumbar spondylosis is described as a degenerative condition whose symptoms recur over a period of time. Hence, the objective of this study is to find out the effect of transcutaneous electrical nerve stimul...
PHYSICAL AND CHEMICAL CHARACTERIZATION OF GREEN SYNTHESIZED SILVER NANOPARTICLES USING STEM OF HIBISCUS VITIFOLIUS L. AND ITS ANTIMICROBIAL AND ANTIOXIDANT POTENTIAL
Objectives: The aim of our work was to synthesize the silver nanoparticle (AgNP) using Hibiscus vitifolius L. stem extract its characterization and evaluation of antimicrobial and antioxidant assay. Materials and Method...
ANTIBACTERIAL ACTIVITY OF THREE PLANT EXTRACTS AGAINST MULTIDRUG RESISTANCE PSEUDOMONAS AERUGINOSA
Objective: The increasing of antibiotic resistance of Pseudomonas aeruginosa causes serious worldwide infection problems. Hence, the objective of the study was to investigate the antibacterial activity of some plants aga...
RELATED SUBSTANCE METHOD DEVELOPMENT AND VALIDATION OF LOXAPINE SUCCINATE IN CAPSULE DOSAGE FORM BY REVERSE PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
Objective: The present study gives a simple, rapid, and accurate stability indicating reverse phase high-performance liquid chromatography method for the determination of loxapine succinate and its related substance (rel...
F FORMULATION DEVELOPMENT AND EVALUATION OF CARBOPOL-INCORPORATED THERMOREVERSIBLE GELS OF PSEUDOEPHEDRINE FOR RECTAL DRUG DELIVERY
Objectives: The present study describes the preparation and evaluation of a Poloxamer 188 (P188)-based thermoreversible gel using Carbopol 934P (C934P) as a mucoadhesive polymer of pseudoephedrine for enhancing the bioav...