ANTICOAGULANT POTENTIAL OF MARINE POLYCHAETE (NEREIS SPECIES)
Journal Title: Journal of Biological and Scientific Opinion - Year 2013, Vol 1, Issue 4
Abstract
There has been an accelerated rate of mortality and morbidity stemming from various chronic diseases worldwide over recent years. Anticoagulants play a pivotal role as agents for the prevention and treatment of thromboembolic disorder. Glycosaminoglycans (GAGs) are linear polysaccharides found in the extracellular matrix and biological fluids of animals where they interact with hundreds of proteins and perform a variety of critical roles. The present study reports the isolation and characterization of glycosaminoglycans from marine polychaete (Nereis sp). The isolated glycosaminoglycans were quantified as 12 g/kg and 0.83 mg/kg from the crude and purified samples respectively. Polychaete showed the anticoagulant activity of the 58 USP units/mg from crude; whereas purified samples showed 114 USP units/mg. The structural characterization of anticoagulant GAG was carried out by Fourier Transform Infrared spectroscopy (FTIR) by comparing with that of the standard GAG. The results of this study could pave the way for further research and exploration of GAGs from marine polychaetes in particular Nereis sp. as an alternative source of heparin.
Authors and Affiliations
Reena Singh, Sunil Sahu, Muthusamy Thangaraj, Velmurugan Karthikeyan
Keywords
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- EP ID EP131200
- DOI 10.7897/2321–6328.01412
- Views 110
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