Anticonvulsant activity of conventional antiepileptic drugs unaltered by vinpocetine in mouse model of epilepsy
Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2007, Vol 1, Issue 1
Abstract
The objective of the study was to determine the effect of combined treatment with vinpocetine (VIN) (a commonly used nootropic drug blocking voltage-gated Na [sup]+ [/sup]channels) and conventional antiepileptic drugs: carbamazepine (CBZ), valproate (VPA), phenobarbital (PB), and phenytoin (PHT) against maximal electroshock-induced convulsions in mice. Vinpocetine (up to 30 mg/kg) did not present either its own anticonvulsant action or have any effect on the protective effect of antiepileptic drugs. This may indicate that not all Na [sup]+ [/sup]channel inhibitors are effective against electroconvulsions. On the other hand, concomitant treatment with vinpocetine and antiepileptics should not require any dose corrections in epileptic patients.
Authors and Affiliations
Kinga K. Borowicz, Mariusz Świąder, Monika Banach
Keywords
Related Articles
- EP ID EP58568
- DOI -
- Views 102
- Downloads 0
Patient care after heart and kidney transplantation – case report
A patient after vascularized organ transplantation requires especially attentive medical care because of the risk of rejection of the transplant, the necessity for monitoring immunosuppressive therapy, and increased susc...
Clinical usefulness of determining C-reactive protein and fibrinogen concentrations and lipid profile in blood serum of patients undergoing surgery due to atherosclerosis
Determination of basic blood biochemical parameters are used as a measure taken in atherosclerosis prophylaxis, or is performed depending on the complications found in the course of the disease. The aim of the study was...
Ultrastructural haemomicrocircular channel links of rat testicle in streptozotocin-induced diabetes
The first changes in rat testicle haemomicrocircular channel links ultrastructural arrangement are noticed already in a 2-week run of streptozotocin-induced diabetes mellitus, and accumulate throughout next periods of th...
Contemporary nursing: objectives and tasks
The objectives, tasks and possibilities of contemporary practically- theoretically oriented nursing is presented, together with consideration of the historical and prognostic context of nursing. The methods of content re...
Combination therapy of basal-cell carcinoma in 31-year-old patient with nevoid basal cell carcinoma syndrome – Case study
Nevoid basal cell carcinoma syndrome (NBCCS) is a rare genetic disease that is manifested in a number of disorders concerning the skin, skeleton, cardiovascular and nervous systems. Various defects which can be observed...