Anticonvulsant activity of conventional antiepileptic drugs unaltered by vinpocetine in mouse model of epilepsy
Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2007, Vol 1, Issue 1
Abstract
The objective of the study was to determine the effect of combined treatment with vinpocetine (VIN) (a commonly used nootropic drug blocking voltage-gated Na [sup]+ [/sup]channels) and conventional antiepileptic drugs: carbamazepine (CBZ), valproate (VPA), phenobarbital (PB), and phenytoin (PHT) against maximal electroshock-induced convulsions in mice. Vinpocetine (up to 30 mg/kg) did not present either its own anticonvulsant action or have any effect on the protective effect of antiepileptic drugs. This may indicate that not all Na [sup]+ [/sup]channel inhibitors are effective against electroconvulsions. On the other hand, concomitant treatment with vinpocetine and antiepileptics should not require any dose corrections in epileptic patients.
Authors and Affiliations
Kinga K. Borowicz, Mariusz Świąder, Monika Banach
Keywords
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