Anticonvulsant and acute neurotoxic characteristics of nicotinic acid benzylamide:a preclinical study.
Journal Title: Pharmacological Reports - Year 2006, Vol 58, Issue 3
Abstract
The aim of this study was to evaluate time-course and dose-response relationships of nicotinic acid benzylamide (Nic-BZA) with regard to its anticonvulsant activity in the maximal electroshock(MES)-induced seizures and acute neurotoxic effects in terms of motor coordination impairment in the chimney test in mice. The experimental determination of both median effective dose (ED(50)) and median toxic dose (TD(50)) allowed for the calculation of protective index (PI) values characterizing a preclinical profile of Nic-BZA. Results indicated that Nic-BZA produced the time-dependent and clear-cut anticonvulsant activity in the MES test and its ED(50) values ranged between 35.7 and 84.0 mg/kg (after the ip administration of the agent at 5 and 60 min, respectively), and between 72.0 and 152.1 mg/kg (at 5 and 60 min, respectively, following the po administration of Nic-BZA). In the chimney test, the TD(50) values for Nic-BZA, after its ip administration ranged between 188.5 and 509.9 mg/kg, whereas following its po administration the TD(50) values for Nic-BZA were between 552 and 1222.1 mg/kg. The PI values for Nic-BZA, calculated at various times after its ip and po administrations (ranging between 3.56 and 17), revealed that the agent has a favorable profile, when considering its both anticonvulsant and acute neurotoxic effects in this preclinical study. Based on this study, one can conclude that Nic-BZA might occur advantageous as a potential antiepileptic drug for breaking seizure attacks in patients with epilepsy.
Authors and Affiliations
Mariusz Świąder, Jarogniew Łuszczki, Ryszard Paruszewski, Stanisław Czuczwar, Waldemar Turski
Keywords
Related Articles
- EP ID EP144364
- DOI -
- Views 80
- Downloads 0
Characterization of an antiproliferative effect of imidazoline receptor ligands on PC12 cells.
The present study aimed at investigating the influence of imidazoline receptor ligands on the proliferation of PC12 cells and the involvement of the sphingosine-1-phosphate (S1P) signaling system in this effect. In cultu...
Effect of ovoalbumin on the survival of an H-Y incompatible skin graft in C57BL/6 mice.
Minor histocompatibility (H) antigens create a barrier to the transplantation of organs and tissues between individuals matched for strong antigens, encoded by the major histocompatibility complex (MHC) in humans and by...
Neurochemical Conference 2009. Genetic and molecular biochemistry of neurological diseases in experiment and clinic. Neuroprotective strategy.
Effects of high-fat mixed-lipid diet and exercise on the antioxidant system in skeletal and cardiac muscles of rats with colon carcinoma.
Epidemiological and experimental studies suggest that eating habits and a sedentary lifestyle play a critical role in the incidence of colon carcinoma. In order to investigate the effects of high-fat mixed-lipid (HFML) d...
Effect of caffeine on the anticonvulsant effects of oxcarbazepine, lamotrigine and tiagabine in a mouse model of generalized tonic-clonic seizures.
Caffeine has been reported to be proconvulsant and to reduce the anticonvulsant efficacy of a variety of antiepileptic drugs (carbamazepine, phenobarbital, phenytoin, valproate and topiramate) in animal models of epileps...