Anticonvulsant and depressant-like activity of ursolic acid stearoyl glucoside isolated from Lantana camara L. (verbanaceae)
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2012, Vol 2, Issue 0
Abstract
Objective: Ursolic acid stearoyl glucoside (UASG), a new terpenoid -isolated from Lantana camara L. was evaluated for its anticonvulsant and depressant activity of was in Wistar albino rats and Swiss mice. Methods: Column chromatography was used to isolate UASG. The intraperitonial administration of UASG (25 and 50 mg/kg) produced a significant depressant effect on CNS. Anticonvulsant potential was experimentally proved and demonstrated through Maximal electroshock (MES) induced seizure, Isoniazid (INH) induced seizure and Assessment of locomotor activity test. Results: Administration of drug reduced spontaneous motor activity (P<0.05), the number and lethality (P<0.01 and P<0.001) of Isoniazid (INH)-induced seizures and inhibition of hind limb extension in (P<0.05 and P<0.001) in Maximal Electroshock (MES)-induced seizures. Conclusions: Research finding suggests that ursolic acid stearoyl glucoside possess anticonvulsant and depressant like effect.
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- EP ID EP233644
- DOI 10.1016/S2222-1808(12)60202-3
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