Anticonvulsant effects of diazepam and nitrazepam in mice

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Anticonvulsant effects of diazepam and nitrazepam in mice

Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2019, Vol 8, Issue 3

Abstract

Introduction The term epilepsy is derived from the Greek word epilam-banein, meaning to attack or seize. People once thought that epileptic individuals were being visited by demons or gods. However, in 400 b.c., the early physician Hippocrates suggested that epilepsy was a disorder of the brain—and he was right. Materials and Methods In the laboratory procedures have been developed in which epileptic activity is closely approximated. The procedures used in this study are Electrical Methods and Chemical Methods. In the present studies all the anticonvulsants were administered intraperitoneally and their peak effect was determined prior to the evaluation of their potencies against electroseizures and chemical seizures. Result The peak anticonvulsant effect of Diazepam and Nitrazepam is 2 hours after intraperitoneal injection whereas for Phenobarbitone it was stretched from 2nd hour to 3rd hour. Conclusion The time of peak effect of phenobarbitone in mice on intraperitoneal administration was ranging from 2nd hour to 3rd hour whereas for diazepam and nitrazepam it was 2nd hour. 0.5 mg/kg of nitrazepam was equipotent to 60 mg/kg of phenobarbitone which in turn was roughly equivalent to 0.5 mg/kg of diazepam.

Authors and Affiliations

Dr G N S Sangeetha Lakshmi

EP ID EP655363
DOI -
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