ANTICONVULSANT POTENCY OF 10 VARIOUS P-ISOPROPOXYPHENYLSUCCINIMIDE DERIVATIVES IN THE MAXIMAL ELECTROSHOCK-INDUCED SEIZURE THRESHOLD MODEL IN MICE
Journal Title: Health Problems of Civilization - Year 2017, Vol 11, Issue 3
Abstract
<b>Background</b>. To compare the anticonvulsant potency of 10 various p-isopropoxyphenylsuccinimide (IPPS) derivatives [i.e., IPPS (IPPS); N-(morpholinomethyl)- IPPS (MM-IPPS); N-(anilinomethyl)-IPPS (AM-IPPS); N-hydroxymethyl-IPPS (HM-IPPS); N-(p-acetylphenyl)-IPPS (AP-IPPS); N-(p-ethoxycarbonylphenylmethyl)-IPPS (ECPM-IPPS); N-(m-bromoanilinomethyl)-IPPS (BAM-IPPS); N-(o-carboxyanilinomethyl)-IPPS (o-CAM-IPPS); N-(m-carboxyanilinomethyl)-IPPS (m-CAM-IPPS); N-(p-carboxyanilinomethyl)-IPPS (p-CAM-IPPS)] in the maximal electroshock-induced seizure threshold (MEST) test in mice. <b>Material and methods</b>. Linear regression analysis of doses of IPPS derivatives and their threshold increases in the MEST test in mice allowed to calculate TID20 values i.e., doses of the tested IPPS derivatives that elevate by 20% the seizure threshold in IPPS-treated mice over the threshold in control animals. <b>Results</b>. A ll t he studied IPPS derivatives (i.e., IPPS, MM-IPPS, HM-IPPS, AP-IPPS, AM-IPPS, ECPM-IPPS, o-CAM-IPPS, m-CAM-IPPS, p-CAM-IPPS and BAM-IPPS) increased in a dose dependent manner the threshold for maximal electroshock-induced seizures in mice. The TID20 values in the MEST test for IPPS, AP-IPPS, AM-IPPS, BAM-IPPS, o-CAM-IPPS, m-CAM-IPPS, p-CAM-IPPS, ECPM-IPPS, HM-IPPS, and MM-IPPS were 60.44 mg/kg, 86.30 mg/kg, 44.69 mg/kg, 103.34 mg/kg, 22.43 mg/kg, 52.84 mg/kg, 80.85 mg/kg, 109.75 mg/kg, 32.62 mg/kg and 53.50 mg/kg, respectively. <b>Conclusions</b>. The studied IPPS derivatives with respect to their anticonvulsant potency in the MEST test can be arranged as follows: o-CAM-IPPS > HM-IPPS > AM-IPPS > m-CAM-IPPS > MM-IPPS > IPPS > p-CAM-IPPS > AP-IPPS > BAM-IPPS > ECPM-IPPS.
Authors and Affiliations
Sergey L. Kocharov, Henry A. Panosyan, Paweł Marzęda, Paula Wróblewska-Łuczka, Ewelina Kochman, Aleksandra Wlaź, Jarogniew J. Łuszczki
Keywords
Related Articles
- EP ID EP321697
- DOI 10.5114/hpc.2017.70010
- Views 65
- Downloads 0
Long-term complications of diabetes and the risk of diabetic foot
Background Chronic complications of diabetes are presently the most vital problem in diabetology and the most significant challenge in the treatment of the diseases. Because of peripheral neuropathy and macroangiopathy,...
Knowledge of coronary arteriosclerosis risk factors and their occurrence and the lifestyles of the first-year medical students
Background Coronary arteriosclerosis risk factors increase the probability of the coronary heart disease and accompanying complications to a significant extent, acting independently from other circumstances. Material an...
Characterization of Staphylococcus Epidermidis isolates cultured from patients with infected hip prostheses
Background Coagulase negative staphylococci are at the forefront of etiologic agents of periprosthetic joint infections (PJIs). The purpose of the study was to characterise causative isolates (n=19) of Staphylococcus epi...
THE ROLE OF PHYSICAL THERAPY IN CANCER TREATMENT
Cancer is a very important problem in both medical and social respects. In recent years, there has been a shift in approach to oncological prevention, diagnostics and treatment. As a result, oncology has become an interd...
SUBJECTIVE ASSESSMENT OF HEALTH AND QUALITY OF LIFE IN WOMEN USING HORMONAL CONTRACEPTIVES
Background. Modern hormonal contraceptives are effective remedies for the prevention of undesirable pregnancies, have a positive impact on the health of women, and serious complications at their using meet seldom. Howeve...