ANTICONVULSANT SCREENING OF HYDRO-ALCOHOLIC ROOT EXTRACT OF BERBERIS ARISTATA IN MICE
Journal Title: Journal of Harmonized Research in Pharmacy - Year 2018, Vol 7, Issue 1
Abstract
Objective: To explore anti-convulsant potential of hydro-alcoholic extract of Berberis aristata (B. aristata) from pentylenetetrazole-induced and maximal electroshock (MES) seizure test. Material & Me thods: The test groups receive different doses (50, 100, 250 and 500 mg/kg) of the hydro-alcoholic extract; however positive control (standard) Phenobarbitone (20 mg/kg) using for Pentylenetetrazole-induced Seizure and Diazepam (1mg/kg) used as standard for maximal electroshock induced seizure. Swiss albino mice weigh about 20-25 g of either sex selected for the investigation. Results: Phytochemical investigation reveals that occurrence of alkaloids, flavonoids in the hydro-alcoholic root extract of Berberis aristata. Acute toxicity study shows no morality action up to 1000 mg/kg dose after 72 h observation. Hydro-alcoholic extract of B. aristata offered a concentration depending upon act of pentylenetetrazole-induced seizure (PTZ) and maximal electroshock induced seizure (MES). Conclusions: These finding suggest that hydro-alcoholic extract of B. aristata remarkable effect in the treatment in epilepsy.
Authors and Affiliations
Suchita Singh Chauhan, Hemant Kumar Sharma
Keywords
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- EP ID EP351012
- DOI 10.30876/JOHR.7.1.2018.1-6
- Views 127
- Downloads 0
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ANTICONVULSANT SCREENING OF HYDRO-ALCOHOLIC ROOT EXTRACT OF BERBERIS ARISTATA IN MICE
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