Antidepressant-like and anxiolytic-like activity of a novel indole amine derivative ADN-2013 in rodents
Journal Title: Medicina Internacia Revuo - Year 2017, Vol 27, Issue 108
Abstract
A novel indolamine derivative, ADN-2013, has been proved to possess a preclinical activity pro le appropriate for the treatment of behavioral and psychological symptoms of dementia. Its antidepressant and anxiolytic properties have been examined in rat and mice models. The receptor mechanisms underlying the antidepressant properties of ADN-2013 have also been elucidated. ADN-2013 signi cantly shortened the immobility time measured in the forced swim test in mice and rats, producing an e ect that was abolished by the dopamine D1-receptor antagonist SCH 23390 in rats. Moreover, ADN-2013 evoked anxiolytic-like activity in both “conditional” and “unconditional” anxiety-like paradigms in mice and rats. From these re- sults, it is likely that direct antagonism toward serotonin 5-HT6 receptors and an indirect e ect of dopamine, acting mostly via D1-like receptors, may be involved in the antidepressant action of ADN-2013. However, the partial agonist activity of ADN-2013 toward D2 receptors, observed in in vitro studies, might also contribute to this effect.
Authors and Affiliations
Anna Wasik, Magdalena Jastrzębska-Więsek, Marcin Kołaczkowski
Keywords
Related Articles
- EP ID EP231744
- DOI -
- Views 45
- Downloads 0
Big Data Algorithms in Medicine: Medical Competence and Critical Judgment Required?
Every week we read about new clinical pictures, that can be diagnosed faster and now with greater certainty than humans, using an algorithm. While doctors have to inform themselves about current studies and guidelines in...
Grzyby nadrewnowe z rodzaju Ganoderma źródłem biologicznie aktywnych triterpenów
Species of the genus Ganoderma are an example of some of the most thoroughly studied rep-resentatives of Basidiomycota both in terms of chemical composition and biological activity. Among the compounds found in this kind...
Warsaw doctors – creators of the polish otorhinolaryngology
The achievements of 19th-century Warsaw physicians and the first decades of the twentieth century who created the Polish otorhinolaryngology are presented briefly. The most famous of them are Teodor Heryng, Alfred Sokolo...
Selen – znaczenie w profilaktyce i terapii schorzeń nowotworowych
Selenium is a trace element supplied to the human body with food of plant and animal origin. It is a component of many enzymes with antioxidant activity, such as: glutathione peroxidase, seleniumprotein P, thioredoxin re...
Das Konzept der Menschenwürde als Wertefundament der Psychiatrie
Human dignity is composing the main theme for the interaction with mentally ill people, which requires certain competence and a certain sensitivity. The action in the psychiatric daily routine in dealing with mentally il...