Abstract

Objective: To formulate and evaluate the antifungal activity of miconazole nitrate proniosomes against Trichophyton rubrum. Methods: Miconazole loaded proniosomal vesicles were prepared by coacervation phase separation method using surfactants, cholesterol and phosphatidylcholine as excipients. The in vitro antifungal activity of prepared vesicles was performed using agar disc diffusion technique. Results: The miconazole nitrate lipid vesicle preparation F5A and F5B showed good antifungal activity with high zones of inhibition i.e. (12.96 ± 0.63) mm and (14.06 ± 0.58) mm than nonvesicular plain drug gel i.e. (10.48 ± 0.79) mm after 3 days at 250 µg/mL concentration (For all comparisons P < 0.05 was considered as significant). Conclusions: Proniosomal preparation resulted in better permeation of the miconazole nitrate and there was a constant increase in zone of inhibition with increase in drug concentration. This study proves antifungal potential of novel proniosomal preparation of miconazole nitrate against Trichophyton rubrum in the treatment of tinea infections.

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