Antidiabetic Activities of Foeniculum Vulgare Mill. Essential Oil in Streptozotocin-Induced Diabetic Rats
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2011, Vol 4, Issue 2
Abstract
Background: Foeniculum vulgare Mill (F. Apiaceae) is an ancient common herb and spice known to the ancient Egyptians and Greeks, traditionally used as a carminative, a weak diuretic and lactation stimulant. Aim: To evaluate the essential oil of Foeniculum vulgare Mill for its hypoglycaemic effect and antioxidant activity in addition to histopathological study in streptozotocin induced diabetic rats. Material and Methods: Rats were divided into 3 groups; normal control, diabetic control, and diabetic group receiving orally Foeniculum vulgare Mill essential oil (30 mg/kg bw).The dose of essential oil was chosen according to its LD50. Serum glucose and whole blood glutathione peroxidase were measured in addition to histopathological study of rats kidney and pancreas. Results: Ingestion of essential oil ofFoeniculum vulgare Mill to diabetic rats corrected the hyperglycemia from (162.5 ± 3.19 mg/dl) to (81.97 ± 1.97 mg/dl) with p<0.05 and the activity of serum glutathione peroxidase from (59.72 ± 2.78 U/g Hb) to (99.60 ± 6.38 U/g Hb) with p<0.05. Also, improved the pathological changes noticed in their kidney and pancreas. Conclusion: Essential oil of Foeniculum vulgare Mill corrected the hyperglycemia and pathological abnormalities in diabetic induced rats, which could be in part through its antioxidative effect and restoring of redox homeostasis. This makes the possibility of its inclusion in antidiabetic drug industry.
Authors and Affiliations
Neveen Abou El-Soud| National Research Center, Complementary Medicine, Cairo, Giza 12311, Egypt, Nabila El-Laithy| National Research Center, Medical Biochemistry, Cairo, Giza 12311, Egypt, Gamila El-Saeed| National Research Center, Medical Biochemistry, Cairo, Giza 12311, Egypt, Mohamed Salah Wahby| National Research Center, Cultivation and Production of Aromatic and Medicinal Plants, Cairo, Giza 12311, Egypt, Mona Khalil| Gizan University, Medical Applied Science, Medical Chemistry, Gizan, Saudi Arabia, Fatma Morsy| National Research Center, Histology and Pathology, Cairo, Giza 12311, Egypt, Nermeen Shaffie| National Research Center, Histology and Pathology, Cairo, Giza 12311, Egypt
Keywords
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- EP ID EP8796
- DOI 10.3889/MJMS.1857-5773.2011.0173
- Views 313
- Downloads 14
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