ANTIDIABETIC ACTIVITY ETHANOLIC LEAVES EXTRACT OF BAUHINIA GALPINII LINN. ALLOXAN INDUCED DIABETIC IN RATS
Journal Title: International Journal of Pharmacognosy - Year 2016, Vol 3, Issue 6
Abstract
Aim of the study: The aim of this study was to investigate the antidiabetic activity of ethanolic leaves extract of Bauhinia galpinii linn. alloxan, induced diabetic in rats. Materials & methods: The adult male albino rats of weight 180-240 gm were selected for the study. The Dose of 100 mg/kg, 250 mg/kg and 500 mg/kg of ethanol extract was selected for the test. All the doses was given orally after making emulsion in vehicle i.e. 1% acacia gum and the standard drug i.e. glimepiride was given orally (10 mg/kg) in the vehicle. Diabetes mellitus was induced by administering intraparitoneal injection of alloxan monohydrate 120 mg/kg to the overnight fasted rats. Blood sample were collected from tail nipping and glucose level was determined by an automatic electronic glucometer. Ethanolic extract of Bauhinia Galpinii Linn. leaves was subjected to anti-diabetic activity in rats where alloxan monohydrate (120 mg/kg b.w., i.p.) used as the diabetogenic agent. A marked rise in fasting blood glucose level observed in diabetic control compare to normal control rats. Results: In the present Ethanolic extract of Bauhinia Galpinii Linn (at 250 and 500 mg/kg) exhibited a dose dependent significant anti-hyperglycemic activity on 4th, 7th and 10th day post treatment. The extract dose of 100 mg/kg also caused reduction in blood glucose level but the results were found statistically insignificant. The antihyperglycemic effect of ethanol extract at was found less effective than the reference standard. Glibenclamide produced a significant reduction in blood glucose compare to diabetic control. When the activity of extract was done by the glucose tolerance test in glucose loaded rats, ethanolic extract showed significant effect on the blood glucose level but extract of 100mg/kg did not show the significant result. Ethanolic extract 250mg/kg and 500mg/kg showed the significant decrease in blood glucose level. Conclusions: The ethanolic extract of Bauhinia galpinii linn. has protective effect against alloxan, induced diabetic in rats.
Authors and Affiliations
Prathavi Chandra Shakya et al.
Keywords
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