ANTIDIABETIC ACTIVITY OF AQUEOUS EXTRACT FROM VIGNA RADIATA IN STREPTOZOCIN INDUCED DIABETIC MICE. Kassahun Dires Ayenewu College of medicine, Debre Berhan University, Debre berhan, Ethiopia, P.O.Box. 445.
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2017, Vol 7, Issue
Abstract
Abstract Vigna radiata is an important medicinl plant that belongs to family of Fabaceae which is widely used in the traditional medicine all over the word. Behind its nutritional acceptance, the grain of this plant is cocked traditionally and consumed for the purpose of lowering the blood glucose level in diabetic patients especially in rural areas. This study was designed to scientifically validate its anti-hyper glycemic activity in diabetic mice. Mice obtained from Ethiopia public health institute were allowed to adapt the experimental room for 3 days before the actual experiment. Mice consumed the standard food (pellet) throughout the experiment. After dissolving streptozocin with 0.9% normal saline, the fresh solution was injected to all mice through intraperitoneal route at a dose of 35 mg/kg. The diabetic mice were divided in two four groups. The first group was treated with glibenclamide (5mg/kg), the second group was treated with normal saline (10 ml/kg) and the last two groups were treated with aqueous extract of Vigna radiata at 200 and 300 mg/kg. Finally, blood glucose levels were measured 1hr, 2hr, 3hr and 4hr after administration of each treatment. The aqueous crude extract at 200 and 300 mg/kg decreased the blood glucose level as compared to the control group (p<0.05).The antidiabetic activity of aqueous extract of Vigna radiata at 200mg/kg was lower than that of the aqueous extract at 300mg/kg. In conclusion, the aqueous crude extract of Vigna radiata possesses significant anti-diabetic activity.
Authors and Affiliations
Kassahun Dires Ayenewu
Keywords
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