ANTIDIABETIC ACTIVITY OF AQUEOUS EXTRACT FROM VIGNA RADIATA IN STREPTOZOCIN INDUCED DIABETIC MICE. Kassahun Dires Ayenewu College of medicine, Debre Berhan University, Debre berhan, Ethiopia, P.O.Box. 445.
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2017, Vol 7, Issue
Abstract
Abstract Vigna radiata is an important medicinl plant that belongs to family of Fabaceae which is widely used in the traditional medicine all over the word. Behind its nutritional acceptance, the grain of this plant is cocked traditionally and consumed for the purpose of lowering the blood glucose level in diabetic patients especially in rural areas. This study was designed to scientifically validate its anti-hyper glycemic activity in diabetic mice. Mice obtained from Ethiopia public health institute were allowed to adapt the experimental room for 3 days before the actual experiment. Mice consumed the standard food (pellet) throughout the experiment. After dissolving streptozocin with 0.9% normal saline, the fresh solution was injected to all mice through intraperitoneal route at a dose of 35 mg/kg. The diabetic mice were divided in two four groups. The first group was treated with glibenclamide (5mg/kg), the second group was treated with normal saline (10 ml/kg) and the last two groups were treated with aqueous extract of Vigna radiata at 200 and 300 mg/kg. Finally, blood glucose levels were measured 1hr, 2hr, 3hr and 4hr after administration of each treatment. The aqueous crude extract at 200 and 300 mg/kg decreased the blood glucose level as compared to the control group (p<0.05).The antidiabetic activity of aqueous extract of Vigna radiata at 200mg/kg was lower than that of the aqueous extract at 300mg/kg. In conclusion, the aqueous crude extract of Vigna radiata possesses significant anti-diabetic activity.
Authors and Affiliations
Kassahun Dires Ayenewu
Keywords
Related Articles
- EP ID EP330612
- DOI -
- Views 100
- Downloads 0
Evaluation of Lepidium sativum Mucilage as Suspending Agent in Paracetamol Suspension
Mucilages are polysaccharide complexes formed from sugar and uronic acid units. Mucilages form slimy masses in water, are typically heterogeneous in composition. The objectives of present investigation were to evaluate L...
“INFLUENCE OF NSAIDS ON BLOOD PRESSURE IN HYPERTENSIVE PATIENTS UNDER TREATMENT: A CROSS SECTIONAL STUDY”
Raised blood pressure is one of the leading risk factors for global mortality and is estimated to have caused 9.4 million deaths. There are chances of using anti-hypertensives and NSAIDs together with increasing age for...
FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLET OF LEVONORGESTREL
Abstract The study was undertaken with an aim to develop and optimized formulation of Hormonal contraceptive, Levonorgestrel by oral drug delivery. Pre-formulation studies were conducted to know the drug excipient compat...
NANOSTRUCTURED LIPID CARRIERS BASED DRUG DELIVERY SYSTEM: A REVIEW
Abstract The main objective of writing this article is to put the emphasis on the importance of Nano structured based drug delivery systems. Although drugs as such can be delivered in the body using different routes but...
ANTIOXIDANT, ANTI-INFLAMMATORY PROPERTIES AND OX-LDL UPTAKE PREVENTION POTENTIAL OF PHYSALIS MINIMA AT TWO STAGES OF MATURITY
Abstract The fruits of Physalis minima, an underexploited food plant, are known to be antioxidant in nature and suitable for consumption in both unripe and ripe stages. Hence it is important to find out the antioxidant a...