Antidiabetic Activity of Aqueous Extract of Solanum nigrum Linn Berries in Alloxan Induced Diabetic Wistar Albino Rats
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 7
Abstract
Introduction: Solanum nigrum Linn. is a common medicinal plant possessing a wide variety of pharmacological activity. Current treatment of diabetes mellitus has plenty of adverse effects necessitating the search of alternate drugs. Aim: Evaluation of antidiabetic effect of Aqueous Extract of Solanum Nigrum Linn Berries (AESNB) in alloxan induced diabetic Wistar rats. Materials and Methods: There were five groups (normal control, diabetic control, AESNB 200 mg/kg/day, ASENB 400 mg/kg/day and standard i.e., glimepride 0.1 mg/kg/day) with six animals in each group. Alloxan was used to induce diabetes in rats. The standard drug glimepride in the dose of 0.1 mg/kg/ day and the test drug AESNB were given orally in the doses of 200 mg/kg/day and 400 mg/kg/day. The fasting blood glucose level was measured by glucometer on day 0, 1,7,14 and 21 after 12 hour. On 21st day after the blood glucose measurement all the animals were sacrificed and their pancreas were analysed histopathologically. The results were analysed statistically by using one-way ANOVA. Results: Aqueous extract of Solanum nigrum Linn berries in the dose of 200 mg/kg/day produced significant blood glucose reduction (p<0.01) from day 7 and 400 mg/kg/day produced highly significant reduction in blood glucose from day 7 (p<0.001). The standard drug glimepride reduced the blood glucose as equal to normal on day 21 (p<0.001). Histopathological examination showed the regeneration of pancreatic beta cells in AESNB group. Conclusion: Aqueous extract of Solanum nigrum Linn berries possess antidiabetic activity.
Authors and Affiliations
MS Umamageswari, TM Karthikeyan, Yasmeen A Maniyar
Keywords
Related Articles
- EP ID EP354524
- DOI 10.7860/JCDR/2017/26563.10312
- Views 55
- Downloads 0
Psychosis in a Case of Dandy-Walker Syndrome: A Case Report
Dandy Walker Syndrome (DWS) is a congenital malformation with brain abnormalities, intellectual disabilities, epilepsy and visible structural changes in particular brain structures. We present here a case of psychosis in...
Solitary Myofibroma of the Mandible in a Six-Year Old-Child: Diagnosis of a Rare Lesion
Myofibroma is a benign uncommon fibroblastic tumour originating from the soft tissue, bone and may affect both children and adults. Radiographically myofibroma presents as unilocular radiolucency. Histologically, typical...
Expression of SOX2 and EGFR in Ameloblastoma, Odontoameloblastoma and Ameloblastic Carcinoma
Introduction: While de novo Ameloblastic Carcinomas (ACs) are easily diagnosed, it is the benign Ameloblastoma (AM) showing areas of malignant transformation which is a diagnostic challenge. SOX2, a transcription factor...
Surveillance of Swine Flu Influenza H1N1 by Chip Based Real Time PCR Technology from the Clinical Specimens in a Tertiary Care Hospital
ABSTRACT Introduction: Influenza viruses are one of the most important viruses which have the ability to cause epidemics and pandemics. Swine flu influenza H1N1 pandemic in 2009 has seen an alarming response from all ove...
Poorly Differentiated Sertoli-Leydig Cell Tumour of Ovary with Heterologous Elements
Sertoli-Leydig Cell Tumour (SLCT) is included under sex-cord stromal tumour of testis or ovary. Ovarian pathology is an extremely rare entity constituting less than 0.5% of all ovarian neoplasms. Majority of the cases pr...