Abstract

Objective: To investigate the antidiabetic effect of A. halimus leaf in streptozotocin-induced diabetic rats. Methods: The aqueous extract of the plant leaf was tested for its efficacy in streptozotocininduced diabetic rats. The extract was evaluated for its acute and short term general toxicity in male mice and for its antihyperglycemic activity using glucose tolerance test in rats. The aqueous extract was subjected to phytochemical screening and determination of total phenolic contents. Results: The statistical data indicated the significant increase in the body weight and decrease in the blood glucose and hepatic levels. The total protein level was significantly increased when treated with the extract. Conclusions: These results suggest that the aqueous leaf extract of A. halimus has beneficial effects in reducing the elevated blood glucose level and hepatic levels in streptozotocin-induced diabetic rats.

Authors and Affiliations