ANTIDIABETIC ACTIVITY OF BAUHINIA VAHLII Wt. and Arn. (CAESALPINIACEAE) ROOT – A BOTANICAL SOURCE FOR THE AYURVEDA DRUG MURVA
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 5
Abstract
Objective: The objective of this study was to evaluate the antidiabetic potential of Bauhinia vahlii Wt. and Arn. (Caesalpiniaceae) root, a botanical source for Murva (Ayurveda drug). Methods: Ethanol extract of B. vahlii root (EEBVR) and aqueous extract of B. vahlii root (AEBVR) prepared were subjected for acute toxicity study adopting Organisation for Economic Cooperation and Development guidelines. Antidiabetic property of EEBVR and AEBVR was screened against Streptozotocin-nicotinamide-induced Diabetes Mellitus (DM). The diabetic animals were administered with standard drug glibenclamide (0.5 mg/kg), EEBVR (200 and 400 mg/kg), and AEBVR (200 and 400 mg/kg) for 21 days. Fasting blood glucose, serum triglycerides, total cholesterol, liver malondialdehyde, reduced glutathione, and glycogen were estimated along with pancreatic histological analysis. Results: EEBVR (400 mg/kg) exerted a marked antidiabetic activity among the extracts at the tested doses, as evidenced by considerable reversal of biochemical parameters that were well supported by the histopathological interpretation of pancreas. Conclusion: This study confirms the antidiabetic potential of B. vahlii root and also its traditional claim in the use of DM.
Authors and Affiliations
KAMATCHI SUNDARA SARAVANAN , VARADHARAJAN MADHAVAN
Keywords
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