Antidiabetic Activity of the Leaves of FicussurForssk (Moraceae) on Alloxan Induced Diabetic Rats
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2018, Vol 4, Issue 1
Abstract
Abstract:To investigate the acute toxicity and antidiabetic potentials of various extracts of the leaves of FicussurForssk on alloxan-induced diabetic rats. Powdered leaves were successively extracted with n-hexane, chloroform and 70% ethanol for three consecutive days respectively and the obtained extracts were assessed for phytochemicals, acute toxicity and antidiabetic activity on albino rats. The acute toxicity was assessed by Lorke’s method. Diabetes was achieved by intraperitoneal injection of alloxan monohydrate (120mg/kg). Blood glucose was determined daily for seven days using a glucometer. On the seventh day of treatment, blood samples were obtained and the serum triglycerides (TG), total cholesterol (TC), glycosylated heamoglobin (GH), urea and high density lipoprotein (HDL) were determined. The active N-hexane fraction was further fractionated by column chromatography packed with silica gel G (60-80mesh) eluting with gradient mixture of n-hexane, dichloromethane and ethanol. The phytochemical screening revealed the presence of terpenoids, tannins, flavonoid and carbohydrates. The lethal dose (LD50) was recorded at 2154mg/kg in the toxicity study. The n-hexane extract showed the highest significant (p<0.05) reduction of 77.7% in blood glucose which was comparable to Glibenclamide (78.3%). Further fractionation yielded five fractions (F1-F5) in which fraction F4 and F5 were the most active with 54.7 and 55.9% reduction of blood glucose. The lipid profile of fraction F4 also exhibited decrease in TG, TC, GH, Urea and increase in HDL. This study reports the LD50 of F. sur to be2154 mg/kg and further confirms its ethnobotanical use of in the treatment of diabetes mellitus and its potential in preventing cardiovascular diseases. Keywords:Ficussur, Moraceae, alloxan-induced diabetes, acute toxicity.
Authors and Affiliations
Suleiman Mikailu
Keywords
Related Articles
- EP ID EP397212
- DOI -
- Views 94
- Downloads 0
Laryngeal Tuberculosis- A Retrospective Study in Three Medical Colleges of West Bengal, India
Abstract:Laryngeal tuberculosis is an extra pulmonary form of tuberculosis and is found in about 2% of all tuberculosis cases. A retrospective analysis of 31 cases of laryngeal tuberculosis was done in the present study...
Perception and Knowledge toward Breast Cancer Prevention and Early Detection: A Comparison between Saudi and Sudanese
The study undertaken the assessment of awareness and specific knowledge, perceived susceptibility, perceived seriousness of breast cancer and perceived benefits of screening for early detection and treatment of women in...
To Study Effect of Transversus Abdominis Plane Block Using 0.25% Levobupivacaine on Post-Operative Analgesia in Patients Undergoing Open Prostectomy
Patients undergoing surgery are most feared of postoperative pain. All the techniques for multimodal analgesia has some or the other side effects. Transversus abdominis plane (TAP) block is newer, effective and comparati...
Knowledge, Attitude and Practices of Nurses to Oral Care for Hospitalized Patients in Services Hospital, Lahore
Abstract: The oral care is essential component of nursing job and it have great impact on patient’s safety and comfort during hospitalization. It prevent from hospital acquired infections. Mortality and morbidity rates a...
Phytochemical Screening and in VitroAntidiabetic Activity of PlumeriaAcuminata Leaves
Abstract:The present study was carried out to evaluate the preliminary phytochemical screening and in vitroantidiabetic activity of Plumeriaacuminataleaves. The leaves of Plumeriaacuminatawas extracted with different sol...