Abstract

Objective: To evaluate the antidiabetic, antihyperlipidemic and in vivo antioxidant potential of aqueous extract of Anogeissus latifolia bark (AEALB) in streptozotocin-nicotinamide (STZ-NIN)- induced type 2 diabetic rats.Methods: Oral acute toxicity for AEALB was performed in rats at 2 g/kg dose. In rats, type 2 diabetes was induced by administration of STZ-NIN (65 mg/kg-110 mg/kg, i.p). AEALB 100, 200 mg/kg dose was administered orally to the diabetic rats up to four weeks. The body weight and blood glucose levels were determined at the end of every week. The haemoglobin, glycosylated haemoglobin, serum lipid profiles and other biochemical parameters were measured on fourth week. The antioxidants level in liver, kidney and pancreas of diabetic rats treated with AEALB were estimated. Results: In the acute toxicity study, AEALB was nontoxic at 2 g/kg in rats. The increased body weight, haemoglobin and decreased blood glucose, glycosylated haemoglobin and other biochemical parameters level was observed in diabetic rats treated with both doses of AEALB compared to diabetic control rats. In diabetic rats, AEALB administration, altered lipid profiles and antioxidants level were reversed to near normal than diabetic control rats. Conclusion: Aqueous extract of Anogeissus latifolia bark possess significant antidiabetic, antihyperlipidemic and in vivo antioxidant activity in type 2 diabetic rats.

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