Antidiabetic Effect of Pleurotus ostreatus (Jacq.ex Fr) kumm. Mushroom on Alloxan-induced Diabetic Rats.
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2013, Vol 1, Issue 2
Abstract
Antidiabetic effects of ethanolic extract of Pleurotus ostreatus (mushroom) on alloxan-induced diabetic rats was studied. The median lethal dose (LD50) of the extract was determined to be 3,472.14 mgkg-1 and a single dose of 380.0, 760.0 and 1140.0 body weight of the extract were intraperitoneally administered as the treatment dose and the blood glucose levels (BGL) examined for 7 hours and 15 hours (prolonged) at 2 and 4 hours intervals respectively. The extract exhibited significant (p<0.05 and p<0.01) reduction in the blood glucose levels of the albino rats. The extract compared favourably with the standard reference drug (metformin) which all gave their maximum BGL reduction at 5 hours duration. The confirmation of antidiabetic potentials of the Pleurotus ostreatus tuber has been justified in this study as claimed by traditional medicine practitionersin Akwa Ibom State.
Authors and Affiliations
Imoh Johnny| Department of Pharmacognosy and Natural Medicine, Faculty of Pharmacy, University of Uyo, P.M.B. 1017 Uyo, Akwa Ibom State-Nigeria, Joseph Okon| Department of Botany and Ecological Studies, Faculty of Science, University of Uyo, P.M.B. 1017 Uyo, Akwa Ibom State-Nigeria.
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