ANTIDIABETIC POTENTIAL OF ETHYL ACETATE EXTRACT OF ADHATODA VASICA NEES ON HIGH FAT DIET AND STREPTOZOTOCIN INDUCED DIABETIC RATS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2019, Vol 8, Issue 4
Abstract
The present study is to investigate the antidiabetic effect of the ethyl acetate extract of Adhatoda vasica Nees on type 2 diabetes induced by high –fat diet and streptozotocin in diabetic male Wistar albino rats. Diabetes is a costly disease with high financial burden. This study is to treat the diabetes using natural resources. The hypoglycemic effect of ethyl acetate extract of Adhatoda vasica Nees was assessed by -using high fat diet (HFD)/ streptozotocin(STZ). The diabetic rats were randomly divided into four groups and treated orally by gavage with vehicle, ethyl acetate extract (200 mg/kg body weight and 400 mg/kg body weight), glibenclamide (10 mg/kg body weight) respectively, T2DM Induction through 3weeks of high fat diet (HFD) intervention was followed by single low dosage of STZ (30mg/kg dissolved in 0.1 mol/L citrate buffer at pH 4.5,i.p). Diabetic rat models showed a significant increase in blood glucose level as compared to the treated animal which was determined by OGTT.T2DM rats have decreased levels of liver glucose 6 phosphate dehydrogenase (G6PD), glutathione reduced (GSH), nitric oxide (No),and antioxidant enzymes. Furthermore, the present study has shown the hypoglycemic, hypolipidemic, and antioxidant the ethyl acetate extract of Adhatoda vasica Nees as confirmed by its ability for ameliorating most of the alteration caused in the studies parameters of diabetic rats.The ethyl acetate extract of Adhatoda vasica Nees may be useful as therapy against oxidative stress and liver damage in type2 diabetes mellitus and is therefore recommended for further studies.
Authors and Affiliations
Vadivelan R.
Keywords
Related Articles
- EP ID EP667764
- DOI -
- Views 119
- Downloads 0
EVALUATION OF THE INTERACTION OF THREE TYPES OF ANTRACICLINES AND NEUROTRASMISORS USING QUANTIC CHEMICAL SIMULATION
In this work we analyze three types of anthracyclines (ACys). The analysis consists of observing how these ACys interact with the neurotransmitters (NT). These drugs are used in the treatment of different types of cancer...
EFFECT OF GLUCOSE CONCENTRATION ON THE SPINAL ANESTHESIA OF 0.4% ENANTIOMERIC EXCESS LEVOBUPIVACAINE (S75:R25)
Background: Baricity is one of the most important factors to influence the characteristics of distribution of the local anesthetic and hence success and spread of the blockade. Bupivacaine is rendered hyperbaric by addin...
IN VITRO ANTI-MICROBIAL AND CYTOTOXIC ACTIVITY ANALYSIS OF CISSUS ADNATA IN DIFFERENT FRACTIONS
This study provides a scientific basis for the use of Cissus adnata in traditional medicine. The whole plant was extracted using methanol and different partitionates were obtained using different organic solvents, like,...
DRUG UTILIZATION PATTERN IN GERIATRICS: A REVIEW
The age 65 and above is considered as geriatrics. The objective of this study was to assess the drug utilization pattern in geriatrics. The study was primarily targeted at the elderly because, as a group they take more d...
MODULATORY EFFECTS OF LNM ON LYMPHOCYTIC APOPTOTIC PATHWAY THROUGH P53, BCL2,
By using immunocytochemistry technique the apoptotic activity of Leinamycin against lymphocytes isolated from Acute Lymphocytic Leukemia patients in comparison with healthy individuals was determined by measuring P53 and...