Antifungal activity of newly synthesized nucleosides containing [1,3,4] oxadiazole-2(3H) one core
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 12
Abstract
In the present study various nucleoside derivatives were synthesized by condensing differently substituted [1,3,4] Oxadiazole-2(3H) one with β-D-1,2,3,4,6-penta-O-acetylglucopyranosyl followed by deacetylation. Structure of obtained compounds has been established by using tools like IR, 1HNMR, and elemental analysis. The compounds have been evaluated for their antifungal behavior against fungi such as Aspergillus flavus, Aspergillus niger and Fusarium oxysporum. The disk diffusion methodology was applied for the values of minimum inhibitory concentration using well known antifungal agent fluconazole as reference standard in cases of all the studies done.
Authors and Affiliations
Shubhra Srivastava, Alok Kumar Srivastava, Afsan Siddiqui
Keywords
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- EP ID EP431726
- DOI 10.9790/5736-1112017381.
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