Antifungal Screening of Bridelia ferruginea Benth (Euphorbiaceae) Stem Bark Extract in Mouthwash Formulations
Journal Title: Journal of Pharmaceutical & Health Sciences - Year 2017, Vol 5, Issue 2
Abstract
The plant Bridelia ferruginea Benth (Euphorbiaceae) has been known for its use in the management of oral thrush ethnomedicinally in various parts of Africa, a practice which has been justified by results of certain scientific studies. The aim of this study was to develop an appropriate dosage formulation, a mouthwash and evaluate the antifungal potential of this dosage formulation against a major causative organism of oral thrush, Candida albicans. Extraction of the stem bark was carried out with boiled distilled water, the extract was formulated into mouthwashes at concentrations of 0.5, 1.0, 1.5, 2.0 and 2.5%w/v. All formulations contained viscosity imparting agent, a sweetener and a preservative. Physical characterisation, viscosity, pH and palatability of the mouthwash formulations were determined. Agar-well diffusion method was used to assess antifungal activity of the formulations against Candida albicans and Nystatin oral suspension was used as reference compound. The results showed that Bridelia ferruginea stem bark extract mouthwash solutions were brown in colour, had agreeable odour and sweet astringent taste. The pH for all concentrations was in the range 5.41-5.63. The viscosity at spindle no 2, 60rpm range between 0.226-0.238 Pa.S for all concentrations studied. The formulations had antifungal activity against Candida albicans. The highest concentration (2.5%w/v) gave mean zone of inhibition of 25.50±0.71mm that was comparable with Nystatin oral suspension 28.00±1.41mm, a reference compound. The foregoing suggests that with little modification in the formulation especially the adjustment of the pH, Bridellia ferruginea mouthwash solutions may be developed into commercially useful preparations.
Authors and Affiliations
Aremu Olusola Isaac, Adewoyin Ayomide Barakat
Keywords
Related Articles
- EP ID EP214894
- DOI -
- Views 130
- Downloads 0
Lactulose efficacy in reduction of nitrogen products, blood potassium and fluid overload in patients with end-stage renal failure
Introduction. Chronic kidney disease (CKD) is a major public health problem that often goes unrecognized until late-stage disease. Patients with chronic kidney disease (CKD) face with uremic toxins and hyperkalemia. Also...
Micronucleus Investigation in Buccal Mucosal Cells of Young Waterpipe Tobacco Smokers in Tehran
Waterpipe Tobacco Smoke(WTS) is an unhealthy life style that may increase the risk of genotoxic responses and chronic diseases such as cancer. Micronucleus test is a successful and reliable method which is used for scree...
Physicochemical Analysis of Margarine, Butter and Butter Oil Samples of Iran’s Markets
Butter, margarine and butter oil are three products which consume daily by Iranian community. Detection of type and existence of synthetic antioxidants (SAs) quantities in the margarine, butter, and butter...
The Efficiency of Bio-adsorption of Heavy Metals from Pharmaceutical Effluent by Rumex crispus L. Seed
The programs of managing waste materials in developing countries are often unsatisfactory and the unreasonable disposal of waste is a major issue in the worldwide. The main aim of the current study is to: Assess the appl...
Production of Clavulanic Acid by Streptomyces clavuligerus in Batch Cultures with Using Wheat Bran as the Source of Carbon
Nowadays Microbial biotechnology is considered as one of the most important and profitable branches of industry. In this approach, by using the generator microorganisms, We are able to produce biotechnological products,...