ANTIHISTAMINIC AND BRONCHODILATING ACTIVITY OF FRUIT BERRIES OF EMBELIA RIBES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 10
Abstract
The present study was designed to evaluate the antihistaminic and bronchodilating activity of ethanolic extract of fruit berries of Embelia ribes brum (ER) by using isolated goat tracheal chain preparation and histamine-induced bronchospasm in guinea pigs. In Histamine induced contraction in isolated goat tracheal chain preparation ER inhibited dose dependent contraction of goat tracheal chain produced by histamine. In histamine-induced bronchospasm in guinea pigs, treatment with ER showed significant protection by prolonging Preconvulsion dyspnoea time (PCD). Thus, ER showed anti-histaminic and bronchodilating activity against histamine and hence possesses potential role in the treatment of asthma.
Authors and Affiliations
Anupama Suralkar , Asha Jadhav , Gayatri Vaidya , Kuldeep Gaikwad
Keywords
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