ANTIHYPERGLYCEMIC ACTIVITY STUDIES WITH MALVA VERTICILLATA LEAVES
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 12
Abstract
Background: Malva verticillata, also known as Chinese mallow and cluster mallow is considered a medicinal herb by traditional medicinal practitioners in Bangladesh The objective of the present study was to evaluate the antihyperglycemic efficacy of methanol extracts of the leaves of the plant (MEMV). Methods: Oral glucose tolerance test (OGTT) was done to evaluate antihyperglycemic efficacy. Results: In oral glucose tolerance tests, MEMV dose-dependently and significantly reduced blood glucose levels in glucose-loaded mice. At doses of 50, 100, 200 and 400 mg per kg body weight, MEMV lowered blood glucose levels by 20.4, 32.0, 37.2, and 46.6%, respectively, compared to control animals. By comparison, a standard antihyperglycemic drug, glibenclamide reduced blood glucose levels by 45.3% at a dose of 10 mg per kg. Conclusion: The leaves can be an effective means for lowering blood glucose in persons with elevated blood glucose levels like people with diabetes.
Authors and Affiliations
Prof. Dr. Mohammed Rahmatullah
Keywords
Related Articles
- EP ID EP627682
- DOI -
- Views 119
- Downloads 0
ASSESSMENT OF ROLES OF COMMUNITY PHARMACISTS IN MANAGEMENT OF DIABETES MELLITUS IN RIVERS STATE, NIGERIA
Diabetes mellitus (DM) is a metabolic disorder of carbohydrate, fat and protein, characterized by hyperglycemia resulting from defective insulin secretion, insulin action or both. DM is one of the major chronic diseases...
THE OUTLOOK OF WIDAL AND MALARIA PARASITE AMONG PATIENTS: A CLINICAL QUERY FOR FEVER IN KOGI STATE SPECIALIST HOSPITAL LOKOJA, KOGI STATE, NIGERIA
Aim: The study was carried out to determine the Outlook of Widal and Malaria Parasite among Patients attending Kogi state specialist Hospital, Lokoja, Kogi State. Materials and Method: A total number of one hundred and t...
SUBSTITUTED BENZIMIDAZOLE A POTENTIAL DRUG CANDIDATE: AN OVERVIEW
Benzimidazole has diverse biological potential and the easy synthetic routes for synthesis have taken attention of the chemists, pharmacologists and researchers. The review of synthetic methods of substituted benzimidazo...
BIODEGRADATION OF PAHS BY CONSORTIUM MICROORGANISMS ISOLATED FROM OIL CONTAMINATED SOIL
Different two isolates of microorganisms were isolated from oil contaminated soil (Baghdad/Al-Dora refinery site). Then these isolates were identified as Bacillus sp. and Aspergillus parasiticus according to their morpho...
ANALYSIS OF DRUG UTILIZATION AND PRESCRIBING PATTERN IN DERMATOLOGY OPD IN TERTIARY CARE HOSPITAL, SAUDI ARABIA
Skin diseases are the major contributors of disease burden in society. It affects individuals of all ages, neonates to elderly. Owing to its chronic nature, it causes serious impact on quality of life of the patient and...