Antihyperlidemic Effects of Mangosteen (<i>Garcinia mangostana</i> L.) Pericarp Ethanolic Extract in High-Carbohydrate Wistar Rats
Journal Title: Journal of Natural Remedies - Year 2017, Vol 17, Issue 4
Abstract
<em>Garcinia mangostana</em> L.has been used as an antioxidant to inhibit oxidation of low density lipoproteins and as an antiobesity agent. The aim of this study was to evaluate the effect of a Mangosteen (<em>G. mangostana</em> L.) Pericarp Ethanolic Extract (MPEE) on lipid profile in rats fed with high-fat diet.The experimental study was conducted in male Wistar rats for 4 weeks and 9 weeks, with rats divided into 5 treatment groups which were normal (standard diet), control (high-fat diet), dose 1 (high-fat diet, MPEE 200 mg/kg b.w.), dose 2 (high-fat diet, MPEE 500 mg/kg b.w.), and orlistat (high-fat diet, orlistat 21.6 mg/kg b.w.) groups. The serum concentration of cholesterol High Density Lipoprotein (HDL) and Low Density Lipoprotein (LDL) and triglycerides of all the animals in each group were determined after the 4 weeks and 9 weeks of treatment. Intrygliceride level, MPEE at the dose of 500 mg/kgbw was more active than the dose of 200 mg/kg. The rats treated with MPEE significantly decreased the LDL level in the 9 weeks at the dose of 200 mg/kg bw and 500 mg/kg bw. However, the HDL level amongthe all groups showed no significant difference.Mangosteen Pericarp Ethanolic Extract (MPEE) has potential as anti-obesity drugs by lowering the tryglyceride and LDL level in high-fat Wistar rats.
Authors and Affiliations
Alkilany Salem Abuzaid
Keywords
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- EP ID EP360930
- DOI 10.18311/jnr/2017/11051
- Views 84
- Downloads 0
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