ANTIHYPERLIPIDEMIC ACTIVITY OF COCCINIA GRANDIS ON HIGH FAT DIET INDUCED WISTAR ALBINO RATS
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2017, Vol 4, Issue 5
Abstract
The aim of conducting this study is to investigate the antihyperlipidemic activity of the ethanolic leaf extracts of Coccinia grandis in High-fat diet (HFD) fed rats to rationalize its primitive medicinal contemplation. Male Wistar albino rats were arbitrarily allocated into four groups: Groups I normal control; Group II HFD control; Group III HFD + C. grandis extract (2 mg/gm), Group IV HFD + Olive oil (2 mg/gm). The whole study lasted for 5th-week. Administration of HFD caused a significant (p<0.05) upsurge in the serum total cholesterol (T.C), LDL-cholesterol, VLDL-cholesterol, triglycerides (T.G). Synchronous administration of ethanolic extract of C. grandis notably (p<0.05) prevented the rise in serum total cholesterol, LDL-cholesterol, VLDL-cholesterol, triglycerides. There was a momentous decrease in body weight and increase in HDL-cholesterol was observed in C. grandis extract treated rats. Thus, this results indicate that, the ethanolic extract of C. grandis have potent antihyperlipidaemic activity. This manuscript may provide optimistic exploratory data to fact-finders and it can be further outspread disengage the bio-active compounds owing to ascertain the antihyperlipidaemic activity in human cell line.
Authors and Affiliations
Dewan Md. Sumsuzzman
Keywords
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