Antihyperlipidemic Activity of Gardenia Gummifera
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 3
Abstract
Ethanolic extract of twigs and gums of Gardenia gummifera (EEGG) was investigated for antihyperlipidemic activity. It was evaluated via in vivo model i.e. Poloxamer-407 induced hyperlipidemia and suspension of Cholesterol + cholic acid induced hyperlipidemia. Poloxamer-407 is an acute model used for determination of preventive antihyperlipidemic properties of EEGG and determination of most efficacious dose i.e. EEGG (250mg/kg), which further used as treatment dose for chronic model (cholesterol +cholic suspension induced hyperlipidemia model). In Poloxamer-407 induced hyperlipidemia models, blood samples were withdrawn at 48th hrs and serum lipid levels and atherogenic index were analyzed. EEGG exhibited significant inhibition of serum TC and LDL levels while as atherogenic coefficient decreased significantly. Effective dose obtained from Poloxamer-407 induced hyperlipidemia model also demonstrated significant inhibition in serum lipid levels (TC and LDL) and atherogenic index (AI,CRR and CR). EEGG also significantly increased serum HDL levels when blood samples were analyzed at 28th day. Liver enzyme assays and Histopathological showed enough evidence to prove its hypolipidemic properties.
Authors and Affiliations
Mr. Chandrashekhar R. Pal
Keywords
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