Antihyperlipidemic effect of crude extract of saffron stigma (Crocus sativus) in healthy male rats
Journal Title: Journal of Medical and Allied Sciences - Year 2017, Vol 7, Issue 1
Abstract
In this study, we investigated for the first time the antihyperlipidemic ef-fects of crude extract of stigmas from Crocus sativus (saffron) against hyperlipidemia induced by tartrazine (synthetic dye) in normal male rats. Thirty adult male albino rats weighing about 150 - 200 g, were divided into 5 groups (n = 6) and daily treatment was given orally. Clinical biochemis-try and metabolic parameters were evaluated at the end of the experiment and after 105 days. (n=6, for all groups). Our data revealed that the meta-bolic parameters like consumption of food and water, pH and urine vol-ume have not been affected; also the difference between liver, right kid-ney and heart weight was not significant. The levels of cholesterol and triglyceride were significantly increased in group 2 and group 3 compared to control group. There was no significant difference in the level of cholesterol and triglyceride in group 4. Treatment with saffron alone did not have any significant effects on the level of fat compared to control group. The oral administration of the crude extract of saffron revealed good hypolipidemic effects in adult male albino rats. These results suggest that aqueous saffron extract reduced plasma cholesterol and decreased triglyceride. Therefore, it could conceivably lead to suitable changes in blood lipid profiles.
Authors and Affiliations
Iliass Lahmass, Sabir Ouahhoud, Assia Sabouni, Mohammed Elyoubi, Redouane Benabbas, Rachid Elmoussaoui, Ennouamane Saalaoui
Keywords
Related Articles
- EP ID EP642854
- DOI 10.5455/jmas.248536
- Views 73
- Downloads 0
Massive pleural effusion from pancreaticopleural fistula: Successfully managed with endoscopic pancreatic duct stenting
We report a case of massive left sided hemorrhagic effusion secondary to pancreaticopleural fistula (PPF) in a young, previously healthy female of 17 years. High pleural fluid amylase levels prompted us for evaluation of...
Unusual case of stroke in young
Thromboembolism is a rare extra-intestinal manifestation of inflammatory bowel disease. Thromboembolic event involving CNS in a case with in-flammatory bowel disease (IBD) is very rare & leads to increase in mor-tality....
Effect of viral hepatitis E on maternal and fetal outcome
Viral hepatitis in pregnancy has been a subject of continuing interest. It is a major cause of enteric transmission of non A and non B hepatitis and is usually self limiting. However in pregnant women, it is more se-vere...
Noughts and crosses: The uncertain future of TB control in India
No abstract
A case of Bochdalek hernia in adult misdiagnosed as pulmonary tuberculosis
Bochdalek hernias are congenital defects resulting from the failure of posterolateral diaphragmatic foramina to fuse in utero. Usually it mani-fests in the neonatal period and occasionally in childhood. Symptomatic Bochd...