Antihypertensive and antioxidant activity of ato mized andean purple corn (Zea mayz L) hydroalcoholic extract in rats.
Journal Title: Revista Peruana de Medicina Experimental y Salud Publica - Year 2008, Vol 25, Issue 2
Abstract
[b][i]Objectives. [/i][/b]To determine the antihypertensive and antioxidant activity of the atomized hydroalcoholic extract of [i]Zea mays L.[/i] (Andean purple corn) in rats with induced hypertension. [b][i]Material and methods.[/i][/b] We used five groups of six Holtzmann rats each, one without hypertension (negative control) and four with hypertension induced by L-NAME: positive control and three groups for the doses of 250 500 and 1000 mg/kg, respectively. The treatment was carried out orally once a day for 25 days. The measurements of mean arterial pressure (MAP), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were conducted leaving a day, it was considered on 18 and 25 started treatments for the study. We measured the levels of malondialdehyde (mmol/L) for determining the antioxidant activity in serum. [b][i]Results.[/i][/b] By day 18 were observed increased levels of blood pressure in both groups. The reduction in blood pressure was dose-dependent, having a greater effect with 1000 mg/kg, resulting in an average decrease of 20.1% of the PAM (p<0.01), 20.7% of the SBP (p<0.01) and 15.7% of DBP (p<0.01) under the positive control group on day 25. There was a 53.3% reduction in the levels of malondialdehyde only in doses of 500 mg/kg. [b][i]Conclusions.[/i][/b] In the experimental conditions, were demonstrated the antihypertensive and antioxidant activity of the atomized hydroalcoholic extract of [i]Zea mays L.[/i]
Authors and Affiliations
Jorge Arroyo, Ernesto Raez, Miguel Rodríguez , Víctor Chumpitaz , Jonny Burga, Walter De la Cruz , José Valencia
Keywords
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