ANTIINFLAMMATORY ACTIVITY OF SOME NOVEL METHYLPHENYL SEMICARBAZONE DERIVATIVES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 6
Abstract
In the present study a series of methylphenylsemicarbazones was synthesized and evaluated for their anti-inflammatory activities by cotton pellet induced granuloma, formalin induced paw edema and carrageenan induced paw edema in rats. Most of the compounds were found to be more or comparable potent than the reference standard drug in all the three animal models. Based on the results of anti-inflammatory study it was found that chloro substitution in the aldehydic moiety and amino substitution in acetophenic moiety of chalcone (compound 28) exhibited better activity. Lengthening of carbon chain also favor anti-inflammatory activity.
Authors and Affiliations
Manmohan Singhal , Arindam Paul , Hemendra Singh
Keywords
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