Antiinflammatory, analgesic and antipyretic effects of dichloromethane stem bark extract of Acacia mellifera
Journal Title: UNKNOWN - Year 2017, Vol 6, Issue 4
Abstract
The present study was designed to assess the in vivo antiinflammatory, analgesic and antipyretic effect of the dichloromethane stem bark extract of Acacia mellifera on experimental animal model at three different dose levels of 50, 100 and 150mg/kg body weight respectively. In addition, phytochemical screening of the extract was done. The inflammatory effect was evaluated by use of carragenaan-induced paw edema in mice, pain was determined using formalin-induced writhing in mice and pyrexia was determined by turpentine-induced pyrexia in rats. The activity of the herbal extract was compared to diclofenac sodium and aspirin. The phytochemical analysis showed the presence of alkaloids, cardiac glycosides, flavonoid, saponins, steroids, terpenoids, tannins and phenolics. The plant extract produced marked anti-inflammatory effect in carrageenaninduced mice paw edema assay, suppressed licking response of animals in both phases of the formalin- induced test and exhibited appreciable antipyretic effects in turpentine-induced pyrexia in rats. The study thus supports the folklore use of the plant in the treatment and management of inflammation, pain and pyrexia.
Authors and Affiliations
Sindani Akumu Veronica, Koech Samson Cheruiyot, Maoga Jane Bosibori, Ireri Moses Munene, Njagi Joan Murugi, Ngugi Mathew Piero
Keywords
Related Articles
- EP ID EP451499
- DOI -
- Views 75
- Downloads 0
Evaluation of antipyretic, antinocieptive and sedative effects of Tribulus terrestris, Mimosa pigra and Alkanna tinctoria methanolic extracts
This study is aimed to evaluate the of antipyretic, antinocieptive and sedative effects of Tribulus terrestris, Mimosa pigra and Alkanna tinctoria methanolic extracts. The methanolic extracts of Mimosa pigra and Alkanna...
GC-MS and FT-IR Profiling of leaves methanol extract from the Pleiospermium alatum (Wall. ex Wt. & Arn) Swingle Rutaceae family
The present study was aimed to analysis of bioactive constituents of leaves from the Pleiospermium alatum (Rutaceae). The methanol extract of the leaves were subjected to Fourier transform infrared spectroscopy (FTIR) an...
Quality standards for Urai Mathirai - A siddha immunomodulator formulation for children
Standardization of Siddha formulations is a major step for establishment of biological activity, consistent chemical profile, or quality control for production and manufacturing of herbal drugs. Urai Mathirai (UM) is a S...
In vitro antibacterial activity of essential oils from Lamiaceae species
Essential oils from Calamintha umbrosa and Nepeta species viz. N. leucophylla; N. hindostana; N. ciliaris and N. clarkei (family Lamiaceae), was tested against six bacterial strains. To evaluate the correlation between t...
Anthelmintic efficacy and safety of selected medicinal plants against mixed gastrointestinal nematodes in artificially infected sheep
There has been widespread resistance to anthelmintics by pathogenic helminths to an extent where there is multi-drug resistance against all major classes of conventional anthelmintics. This world-wide phenomenon calls fo...