Antiinflammatory, analgesic and antipyretic effects of dichloromethane stem bark extract of Acacia mellifera

Journal Title: The Journal of Phytopharmacology - Year 2017, Vol 6, Issue 4

Abstract

The present study was designed to assess the in vivo antiinflammatory, analgesic and antipyretic effect of the dichloromethane stem bark extract of Acacia mellifera on experimental animal model at three different dose levels of 50, 100 and 150mg/kg body weight respectively. In addition, phytochemical screening of the extract was done. The inflammatory effect was evaluated by use of carragenaan-induced paw edema in mice, pain was determined using formalin-induced writhing in mice and pyrexia was determined by turpentine-induced pyrexia in rats. The activity of the herbal extract was compared to diclofenac sodium and aspirin. The phytochemical analysis showed the presence of alkaloids, cardiac glycosides, flavonoid, saponins, steroids, terpenoids, tannins and phenolics. The plant extract produced marked anti-inflammatory effect in carrageenaninduced mice paw edema assay, suppressed licking response of animals in both phases of the formalin- induced test and exhibited appreciable antipyretic effects in turpentine-induced pyrexia in rats. The study thus supports the folklore use of the plant in the treatment and management of inflammation, pain and pyrexia.

Authors and Affiliations

Sindani Akumu Veronica, Koech Samson Cheruiyot, Maoga Jane Bosibori, Ireri Moses Munene, Njagi Joan Murugi and Ngugi Mathew Piero

Keywords

Related Articles

Kinetic, sorption isotherms, pseudo-first-order model and pseudo-second-order model studies of Cu(II) and Pb(II) using defatted Moringa oleifera seed powder

In the recent decades, there has been a concern on heavy metals in waste water and high cost of conventional methods of removing heavy metals, for this reason search on adsorbents of biological origin which is low cost...

Comparative assessment of Chemosuppressive activity of three Chinese teas on Plasmodium berghei infected mice

Malaria, a hazardous infirmity caused by a parasitic malady of the red blood cells, is without question harming to the wellbeing. In the present investigation, the chemosuppresive and haematopoietic activities of 200 mg...

Antidiabetic Herbal Drugs and Polyherbal Formulation Used For Diabetes: A Review

This dreadful disease is found in all parts of the world and is becoming a serious threat to mankind health. It is caused by the deficiency or ineffective production of insulin by pancreas which results in increase or...

Enumerations on phytochemical, pharmacological and ethnobotanical properties of Cassia fistula Linn: yellow shower

Indian Laburnum or Yellow shower (Cassia fistula Linn.) of Fabaceae (caesalpiniaceae) is a semi-wild deciduous and ornamental tree with long and cylindrical fruits. It is a native of tropical Asia widely cultivated in...

Gastroprotective effect of ethanolic extract of Parmelia perlata in rats

Gastric ulcer disease (GUD) is one of the major gastrointestinal disorders which occur due to an imbalance between offensive (acid, pepsin and Helicobacter pylori) and defensive (mucin, prostaglandin and bicarbonate) f...

Download PDF file
  • EP ID EP49745
  • DOI -
  • Views 146
  • Downloads 0

How To Cite

Sindani Akumu Veronica, Koech Samson Cheruiyot, Maoga Jane Bosibori, Ireri Moses Munene, Njagi Joan Murugi and Ngugi Mathew Piero (2017). Antiinflammatory, analgesic and antipyretic effects of dichloromethane stem bark extract of Acacia mellifera. The Journal of Phytopharmacology, 6(4), -. https://europub.co.uk/articles/-A-49745